[4-(2-Aminoethyl)phenyl]dimethylaminedihydrochloride

Base Information

• Chemical Name: [4-(2-Aminoethyl)phenyl]dimethylaminedihydrochloride
• CAS No.: 102880-23-9
• Molecular Formula: C10H18Cl2N2
• Molecular Weight: 237.16932
• Hs Code.: 2921590090
• Mol file: 102880-23-9.mol

Synonyms:[4-(2-Aminoethyl)phenyl]dimethylaminedihydrochloride;4-(dimethylamino)Benzeneethanamine Dihydrochloride

Chemical Property of [4-(2-Aminoethyl)phenyl]dimethylaminedihydrochloride

Chemical Property:

• PSA: 29.26000
• LogP: 3.55810

Purity/Quality:

98%min ^*data from raw suppliers

[4-(2-Aminoethyl)phenyl]dimethylamineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [4-(2-Aminoethyl)phenyl]dimethylaminedihydrochloride

There total 2 articles about [4-(2-Aminoethyl)phenyl]dimethylaminedihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline (22568-06-5) → 4-dimethylamino-phenethylamine; dihydrochloride (102880-23-9)

Guidance literature:

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline; With hydrogenchloride; In methanol; diethyl ether; water; at 0 ℃; for 0.5h;

With palladium on activated charcoal; hydrogen; In methanol; diethyl ether; water; at 0 - 20 ℃; for 16h;

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) → 4-dimethylamino-phenethylamine; dihydrochloride (102880-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / 3 h / 120 °C / Sealed tube

2.1: hydrogenchloride / methanol; water; diethyl ether / 0.5 h / 0 °C

2.2: 16 h / 0 - 20 °C

With hydrogenchloride; ammonium acetate; acetic acid; In methanol; diethyl ether; water;

Reference yield:

methyl (2E)-3-(1-oxo-2,3-dihydro-1H-inden-5-yl)-2-propenoate (786647-54-9) + 4-dimethylamino-phenethylamine; dihydrochloride (102880-23-9) → (E)-3-(1-((4-(dimethylamino)phenethyl)amino)-2,3-dihydro-1H-inden-5-yl)propenoic acid methyl ester

Guidance literature:

methyl (2E)-3-(1-oxo-2,3-dihydro-1H-inden-5-yl)-2-propenoate; 4-dimethylamino-phenethylamine; dihydrochloride; With toluene-4-sulfonic acid; sodium hydroxide; In toluene; at 130 ℃; for 4h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;

upstream raw materials:

4-dimethylamino-benzaldehyde

(E)-N,N-dimethyl-4-(2-nitrovinyl)aniline

Downstream raw materials:

N-(4-dimethylamino-phenethyl)-benzamide