AKOS B030368

Base Information

• Chemical Name: AKOS B030368
• CAS No.: 674788-53-5
• Molecular Formula: C7H8N4O
• Molecular Weight: 164.16462
• Hs Code.: 2933990090
• Mol file: 674788-53-5.mol

Synonyms:AKOS B030368;1-Ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Chemical Property of AKOS B030368

Chemical Property:

• Boiling Point: 358.2±34.0 °C(Predicted)
• PKA: 0.83±0.20(Predicted)
• PSA: 63.57000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 0.13950

Purity/Quality:

1-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B030368

There total 3 articles about AKOS B030368 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate (923283-57-2) + formamidine acetic acid (3473-63-0) → 1-ethyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol (674788-53-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 110 ℃; for 1h;

Reference yield:

methyl?4-amino-1-ethyl-1H-pyrazole-3-carboxylate (923283-58-3) + formamidine acetic acid (3473-63-0) → 1-ethyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol (674788-53-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 120 ℃; for 3h;

Reference yield:

methyl 1-ethyl-4-nitro-1H-pyrazole-3-carboxylate (923283-30-1) → 1-ethyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol (674788-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 3 h / 120 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; butan-1-ol;

upstream raw materials:

methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate

formamidine acetic acid

methyl?4-amino-1-ethyl-1H-pyrazole-3-carboxylate

methyl 1-ethyl-4-nitro-1H-pyrazole-3-carboxylate