3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 1142192-57-1
• Molecular Formula: C₈H₄F₃IN₂
• Molecular Weight: 312.033
• Hs Code.: 2933399990
• Mol file: 1142192-57-1.mol

Synonyms:3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine;3-Iodo-5-(trifluoroMethyl)-7-azaindole

Chemical Property of 3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

• PSA: 28.68000
• LogP: 3.18630

Purity/Quality:

99%, ^*data from raw suppliers

3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

• Uses: 3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is used as a reactant in the preparation of azaindole derivatives as kinase modulators.

Technology Process of 3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

There total 4 articles about 3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1036027-54-9) → 3-iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1142192-57-1)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

3-iodo-5-(trifluoromethyl)pyridine-2-amine (211308-82-6) → 3-iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1142192-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 20 °C

2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 12 h / 80 °C

3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; iodine; triethylamine; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

5-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)pyridin-2-amine (1036027-52-7) → 3-iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (1142192-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 12 h / 80 °C

2: iodine; potassium hydroxide / N,N-dimethyl-formamide / 12 h / 20 °C

With potassium tert-butylate; iodine; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

upstream raw materials:

3-iodo-5-(trifluoromethyl)pyridine-2-amine

5-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)pyridin-2-amine

2-amino-5-trifluoromethylpyridine

5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

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