5-(Trifluoromethyl)pyridin-2-amine

Base Information

Chemical Name:5-(Trifluoromethyl)pyridin-2-amine
CAS No.:74784-70-6
Molecular Formula:C6H5F3N2
Molecular Weight:162.114
Hs Code.:29333990
European Community (EC) Number:623-444-2
DSSTox Substance ID:DTXSID70352866
Nikkaji Number:J2.152.093D
Wikidata:Q27453673
Mol file:74784-70-6.mol

Synonyms:2-Pyridinamine,5-(trifluoromethyl)-;2-Amino-5-trifluoromethylpyridine;

Suppliers and Price of 5-(Trifluoromethyl)pyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-?Amino-?5-?(trifluoromethyl)?pyridine
5g
$ 110.00

TCI Chemical
2-Amino-5-(trifluoromethyl)pyridine >97.0%(GC)(T)
25g
$ 191.00

TCI Chemical
2-Amino-5-(trifluoromethyl)pyridine >97.0%(GC)(T)
5g
$ 64.00

SynQuest Laboratories
2-Amino-5-(trifluoromethyl)pyridine 98%
10 g
$ 11.00

SynQuest Laboratories
2-Amino-5-(trifluoromethyl)pyridine 98%
25 g
$ 25.00

SynQuest Laboratories
2-Amino-5-(trifluoromethyl)pyridine 98%
100 g
$ 85.00

SynQuest Laboratories
2-Amino-5-(trifluoromethyl)pyridine 98%
500 g
$ 370.00

Sigma-Aldrich
2-Amino-5-(trifluoromethyl)pyridine 97%
1g
$ 207.00

Sigma-Aldrich
2-Amino-5-(trifluoromethyl)pyridine 97%
250mg
$ 81.20

Matrix Scientific
2-Amino-5-(trifluoromethyl)pyridine 97%
25g
$ 29.00

Total 135 raw suppliers

Chemical Property of 5-(Trifluoromethyl)pyridin-2-amine

Chemical Property:

Vapor Pressure:0.217mmHg at 25°C
Melting Point:45 °C
Refractive Index:1,533
Boiling Point:208.2 °C at 760 mmHg
PKA:4.55±0.13(Predicted)
Flash Point:79.7 °C
PSA：38.91000
Density:1.368 g/cm³
LogP:2.26380
Storage Temp.:Room temperature.
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:162.04048265
Heavy Atom Count:11
Complexity:134

Purity/Quality:

98% ^*data from raw suppliers

2-?Amino-?5-?(trifluoromethyl)?pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,T
Hazard Codes:Xn,Xi,T
Statements: 20/21/22-36/37/38-25
Safety Statements: 26-36/37/39-45-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC=C1C(F)(F)F)N
Uses 2-?Amino-?5-?(trifluoromethyl)? is a reagent used in the synthesis of selective inhibitors of urokinase plasminogen activator in a non-cytotoxic form of cancer therapy.

Technology Process of 5-(Trifluoromethyl)pyridin-2-amine

There total 3 articles about 5-(Trifluoromethyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69045-78-9
2-chloro-5-(Trichloromethyl)-pyridine

: 74784-70-6
2-amino-5-trifluoromethylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 54.5 percent / antimony trifluoride / 0.17 h / Heating

2: 39 percent / aq. ammonia / 8 h / 180 °C

With ammonium hydroxide; antimony(III) fluoride;