(+)-Biotin-PEG12-CH2CH2COONHS Ester

Base Information

Chemical Name:(+)-Biotin-PEG12-CH2CH2COONHS Ester
CAS No.:365441-71-0
Molecular Formula:C21H32N4O8S
Molecular Weight:941.09138
Hs Code.:2942000090
Mol file:365441-71-0.mol

Synonyms:(+)-Biotin-PEG12-CH2CH2COONHS Ester;(+)-Biotin-PEG24-NHS Ester;(+)-Biotin-PEG24-NHS Ester;Biotin-PEG12-NHS ester;EZ-Link NHS-PEG12-Biotin;alpha-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]-omega-[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]-poly(oxy-1,2-ethanediyl)

Suppliers and Price of (+)-Biotin-PEG12-CH2CH2COONHS Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EZ-LinkNHS-PEG12-Biotin
250mg
$ 1265.00

purepeg
(+)-Biotin-PEG12-NHSEster min.97%
250 mg
$ 400.00

Medical Isotopes, Inc.
EZ-LinkNHS-PEG12-Biotin
250 mg
$ 2275.00

Iris Biotech GmbH
Biotin-dPEG?(24)-NHS
1 g
$ 2322.00

Iris Biotech GmbH
Biotin-dPEG(12)-NHS
1 g
$ 1890.00

Iris Biotech GmbH
Biotin-dPEG?(24)-NHS
50 mg
$ 513.00

Iris Biotech GmbH
Biotin-dPEG(12)-NHS
50 mg
$ 310.50

dPEG
NHS-dPEG???-biotin
50 mg
$ 250.00

BroadPharm
Biotin-PEG12-NHSester 98%
100 MG
$ 380.00

BroadPharm
Biotin-PEG12-NHSester 98%
250 MG
$ 550.00

Total 14 raw suppliers

Chemical Property of (+)-Biotin-PEG12-CH2CH2COONHS Ester

Chemical Property:

PSA：177.67000
LogP:0.84530
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:DMF (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

EZ-LinkNHS-PEG12-Biotin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Biotin-PEG12-NHS ester is an aqueous soluble, amine reactive biotinylation reagent that can conjugate with lysine or other N-terminal amine moleculeat pH 7-9.
Uses EZ-Link NHS-PEG12-Biotin is a reactant in the preparation of biotin-CTT54 ligands and multivalent PSMA inhibitor-guided streptavidin conjugates for targeting prostate cancer cells.

Technology Process of (+)-Biotin-PEG12-CH2CH2COONHS Ester

There total 8 articles about (+)-Biotin-PEG12-CH2CH2COONHS Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 252881-76-8
biotin-PEG₃-acid

: 1253286-56-4,365441-71-0
2,5-dioxopyrrolidin-1-yl 14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanoate

Guidance literature:: With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

: 252881-74-6,872340-65-3
tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

: 1253286-56-4,365441-71-0
2,5-dioxopyrrolidin-1-yl 14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: diisopropyl-carbodiimide / dichloromethane / 20 °C

With trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;

Reference yield:

: 58-85-5,22879-79-4
biotin

: 1253286-56-4,365441-71-0
2,5-dioxopyrrolidin-1-yl 14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanoate

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropyl-carbodiimide / N,N-dimethyl-formamide / 45 °C

2: dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: diisopropyl-carbodiimide / dichloromethane / 20 °C

With trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;