1,3-Dimethyl-2-butoxybenzene

Base Information

• Chemical Name: 1,3-Dimethyl-2-butoxybenzene
• CAS No.: 56052-33-6
• Molecular Formula: C12H18O
• Molecular Weight: 178.274
• Mol file: 56052-33-6.mol

Synonyms:1,3-Dimethyl-2-butoxybenzene;2-Butoxy-1,3-dimethylbenzene

Chemical Property of 1,3-Dimethyl-2-butoxybenzene

Chemical Property:

• Boiling Point: 242.5±9.0 °C(Predicted)
• PSA: 9.23000
• Density: 0.911±0.06 g/cm3(Predicted)
• LogP: 3.48230

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dimethyl-2-butoxybenzene

There total 2 articles about 1,3-Dimethyl-2-butoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-dimethyl-1-chlorobenzene (6781-98-2) + butan-1-ol (71-36-3) → 2-butoxy-1,3-dimethylbenzene (56052-33-6)

Guidance literature:

With racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium diacetate; caesium carbonate; In toluene; at 23 ℃; for 39h;

DOI:10.1021/ja016863p

Reference yield: 44.0%

1-bromo-butane (109-65-9) + 2.6-dimethylphenol (576-26-1,25134-01-4) → 2-butoxy-1,3-dimethylbenzene (56052-33-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 70 ℃; for 48h;

DOI:10.1021/jo0106142

Reference yield: 91.0%

2-butoxy-1,3-dimethylbenzene (56052-33-6) → 2-butoxy-5-iodo-1,3-dimethyl-benzene (605666-41-9)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; for 0.25h; Heating;

DOI:10.1021/jo0106142

upstream raw materials:

1-bromo-butane

2.6-dimethylphenol

2,6-dimethyl-1-chlorobenzene

butan-1-ol

Downstream raw materials:

4-Butoxy-3,5-dimethyl-benzenesulfonyl chloride

2-butoxy-5-iodo-1,3-dimethyl-benzene

Refernces

• 1、 Torraca,Huang,Parrish,Buchwald. "An efficient intermolecular palladium-catalyzed synthesis of aryl ethers [17]". . p. 10770 - 10771. Retrieved 2007/10/03.