1-(2-Amino-4-bromo-5-fluorophenyl)ethanone

Base Information

Chemical Name:1-(2-Amino-4-bromo-5-fluorophenyl)ethanone
CAS No.:937816-89-2
Molecular Formula:C8H7BrFNO
Molecular Weight:232.05
Hs Code.:2922399090
DSSTox Substance ID:DTXSID90585311
Wikidata:Q82477229
Mol file:937816-89-2.mol

Synonyms:937816-89-2;1-(2-amino-4-bromo-5-fluorophenyl)ethanone;Ethanone, 1-(2-amino-4-bromo-5-fluorophenyl)-;1-(2-AMINO-4-BROMO-5-FLUOROPHENYL)ETHAN-1-ONE;1-(2-amino-4-bromo-5-fluorophenyl)-Ethanone;2'-Amino-4'-bromo-5'-fluoroacetophenone;1-(2-Amino-4-bromo-5-fluoro-phenyl)-ethanone;SCHEMBL15067720;DTXSID90585311;EN300-672909;G11069

Suppliers and Price of 1-(2-Amino-4-bromo-5-fluorophenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
1-(2-Amino-4-bromo-5-fluoro-phenyl)-ethanone ＞97%
1 G
$ 520.00

Total 4 raw suppliers

Chemical Property of 1-(2-Amino-4-bromo-5-fluorophenyl)ethanone

Chemical Property:

PSA：43.09000
LogP:2.95420
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:230.96950
Heavy Atom Count:12
Complexity:188

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Amino-4-bromo-5-fluoro-phenyl)-ethanone ＞97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC(=C(C=C1N)Br)F

Technology Process of 1-(2-Amino-4-bromo-5-fluorophenyl)ethanone

There total 4 articles about 1-(2-Amino-4-bromo-5-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 656-64-4
3-bromo-4-fluoroaniline

: 75-05-8,26809-02-9
acetonitrile

: 937816-89-2
1-(2-amino-4-bromo-5-fluorophenyl)ethanone

Guidance literature:: 3-bromo-4-fluoroaniline; acetonitrile; With boron trichloride; In n-heptane;

With aluminium trichloride; In n-heptane; Heating;

With hydrogenchloride; In n-heptane; Further stages.; Heating;
DOI:10.1021/jm061428x

Reference yield:

: 1395493-30-7
2-amino-4-bromo-5-fluorobenzoic acid methyl ester

: 937816-89-2
1-(2-amino-4-bromo-5-fluorophenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; tetrahydrofuran; methanol / 16 h / 20 °C

2: 1,1'-carbonyldiimidazole; triethylamine / tetrahydrofuran / 48 h / 0 - 60 °C

3: tetrahydrofuran / 1 h / -78 - -40 °C

With triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 1374208-42-0
3-fluoro-4-bromo-6-aminobenzoic acid

: 937816-89-2
1-(2-amino-4-bromo-5-fluorophenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole; triethylamine / tetrahydrofuran / 48 h / 0 - 60 °C

2: tetrahydrofuran / 1 h / -78 - -40 °C

With triethylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran;