656-64-4

Usage

Uses

Used in Organic Synthesis:
3-Bromo-4-fluoroaniline is used as an intermediate for the synthesis of agrochemicals and active pharmaceutical ingredients. Its unique combination of bromine and fluorine atoms allows for the creation of a wide range of derivatives with potential applications in both the agricultural and pharmaceutical industries.
Used in Agrochemical Industry:
3-Bromo-4-fluoroaniline is used as a key intermediate in the development of agrochemicals, specifically for the synthesis of pesticides and herbicides. Its presence in these compounds can enhance their effectiveness in controlling pests and unwanted plant growth, contributing to increased crop yields and protection.
Used in Pharmaceutical Industry:
3-Bromo-4-fluoroaniline is utilized as a building block in the synthesis of active pharmaceutical ingredients. Its structural features can be incorporated into drug molecules to modulate their properties, such as solubility, stability, and biological activity, leading to the development of new and improved medications for various therapeutic areas.

InChI:InChI=1/C6H5BrFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 452-62-0 3-bromo-4-fluorotoluene 
• 836619-77-3 tert-butyl N-(3-bromo-4-fluorophenyl)carbamate 
• 13194-71-3 2-bromo-4-methyl-aniline; hydrochloride 
• 701-45-1 2-bromo-1-fluoro-4-nitrobenzene 
• 1007-16-5 3-bromo-4-fluorobenzoic acid 

Downstream Products

• 1627-47-0 3-methyl-isoxazole-4,5-dione 4-[(3-bromo-4-fluoro-phenyl)-hydrazone] 
• 77123-63-8 4-fluoro-3-<(trimethylsilyl)ethynyl>aniline 
• 227312-00-7 4-<(3-bromo-4-fluorophenyl)amino>-6-fluoropyrido<3,2-d>pyrimidine 
• 909104-94-5 3-bromo-4-fluoro-[bis-(2-hydroxy-6-oxo-cyclohex-1-enyl)-amino]-benzene 
• 937817-34-0 2-[2-(2-acetyl-5-bromo-4-fluorophenylamino)acetylamino]benzoic acid methyl ester 
• 811842-30-5 2-bromo-1-fluoro-4-iodobenzene 
• 425378-77-4 4-fluoro-3-(pyridin-3-yl)phenylamine 
• 214485-52-6 4-[(3-Bromo-4-fluorophenyl)amino]-6-nitro-quinoline-3-carbonitrile 
• 185827-14-9 1(3-bromo-4-fluorophenyl)3-hydroxypyrrolidin-2-one 
• 890129-90-5 3-cyclopropyl-4-fluoro-aniline 
• 631912-19-1 3-bromo-4-fluorobenzene-1-sulfonyl chloride 
• 1166990-89-1 (3-bromo-4-fluorophenyl)hydrazine hydrochloride 
• 1202890-27-4 ethyl 7-(4-(3-bromo-4-fluorophenylcarbamoyl)phenoxy)-6-chlorochroman-4-carboxylate 
• 1228352-62-2 N-(3-bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 

Relevant academic research and scientific papers

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

NOVEL TRIAZINE COMPOUND, AND ORGANIC ELECTRONIC ELEMENT AND PLANT-GROWING LIGHTING THAT USE THE SAME

PROBLEM TO BE SOLVED: To provide a triazine compound which has a high triplet energy level and excellent heat resistance, and can be used as an organic electronic element material realizing an element with high efficiency, low voltage and a long life. SOLUTION: In the triazine compound, as represented by the general formula [1] in the figure, a triazine backbone moiety is linked to a dibenzofuran or dibenzothiophene backbone moiety via a biphenyl backbone moiety, where X is an oxygen atom or sulfur atom. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

Synthesis and structure-activity relationships of new quinolone-type molecules against trypanosoma brucei

Human African trypanosomiasis (HAT) or sleeping sickness is caused by two subspecies of Trypanosoma brucei, Trypanosoma brucei gambiense, and Trypanosoma brucei rhodesiense and is one of Africa's old plagues. It causes a huge number of infections and cases of death per year because, apart from limited access to health services, only inefficient chemotherapy is available. Since it was reported that quinolones such as ciprofloxacin show antitrypanosomal activity, a novel quinolone-type library was synthesized and tested. The biological evaluation illustrated that 4-quinolones with a benzylamide function in position 3 and cyclic or acyclic amines in position 7 exhibit high antitrypanosomal activity. Structure-activity relationships (SAR) are established to identify essential structural elements. This analysis led to lead structure 29, which exhibits promising in vitro activity against T. b. brucei (IC50 = 47 nM) and T. b. rhodesiense (IC50 = 9 nM) combined with low cytotoxicity against macrophages J774.1. Screening for morphological changes of trypanosomes treated with compounds 19 and 29 suggested differences in the morphology of mitochondria of treated cells compared to those of untreated cells. Segregation of the kinetoplast is hampered in trypanosomes treated with these compounds; however, topoisomerase II is probably not the main drug target.

Substituted benzazoles and methods of their use as inhibitors of Raf kinase

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.

Facile Synthesis of Ethynylated Benzoic Acid Derivatives and Aromatic Compounds via Ethynyltrimethylsilane

The coupling reaction between an aromatic halide and ethynyltrimethylsilane under the catalysis of palladium(0) generated in situ, followed by treatment of the (trimethylsilyl)ethynyl product with potassium carbonate in methanol at ambient temperatures, provides a simple approach to various ethynylated benzoic acid derivatives and other aromatic compounds.The conditions for the removal of the trimethylsilyl group were very mild, so that base-sensitive functionalities on the aromatic moiety could be tolerated.