656-64-4

Basic information

• Product Name: 3-Bromo-4-fluoroaniline
• Synonyms: 3-Bromo-4-fluoroanil;3 - broMine - 4 - fluoro aniline;3-Bromo-4-fluorophenylamine;3-BROMO-4-FLUOROANILINE;BENZENAMINE, 3-BROMO-4-FLUORO-;3-Bromo-4-fluoroaniline 98%;3-Bromo-4-fluoroaniline98%;3-Bromo-4-fluoroanline
• CAS NO: 656-64-4
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.01
• Product Categories: Miscellaneous;Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Aniline series;Fluorine series;Oxetanes
• Mol File: 656-64-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 34-36°C
• Boiling Point: 235°C
• Flash Point: 235°C
• Appearance: Colorless liquid
• Density: 1.694 g/cm³
• Vapor Pressure: 0.0238mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.58±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-Bromo-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-fluoroaniline(656-64-4)
• EPA Substance Registry System: 3-Bromo-4-fluoroaniline(656-64-4)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38-36-36/38-20/21/22
• Safety Statements: 26-36/37/39-36/37
• RIDADR: UN2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 656-64-4(Hazardous Substances Data)

Usage

Uses

3-Bromo-4-fluoroaniline is used in organic synthesis as an intermediate of agrochemicals and active pharmaceutical ingredient.

InChI:InChI=1/C6H5BrFN/c7-5-3-4(9)1-2-6(5)8/h1-3H,9H2

Upstream product

• 836619-77-3 tert-butyl N-(3-bromo-4-fluorophenyl)carbamate 
• 13194-71-3 2-bromo-4-methyl-aniline; hydrochloride 
• 452-62-0 3-bromo-4-fluorotoluene 
• 1072-85-1 o-fluorobromobenzene 
• 701-45-1 2-bromo-1-fluoro-4-nitrobenzene 
• 1007-16-5 3-bromo-4-fluorobenzoic acid 

Downstream Products

• 1627-47-0 3-methyl-isoxazole-4,5-dione 4-[(3-bromo-4-fluoro-phenyl)-hydrazone] 
• 227312-00-7 4-<(3-bromo-4-fluorophenyl)amino>-6-fluoropyrido<3,2-d>pyrimidine 
• 909104-94-5 3-bromo-4-fluoro-[bis-(2-hydroxy-6-oxo-cyclohex-1-enyl)-amino]-benzene 
• 77123-60-5 3-ethynyl-4-fluoroaniline 
• 710351-24-9 2-bromo-1-fluoro-4-isothiocyanatobenzene 
• 425378-77-4 4-fluoro-3-(pyridin-3-yl)phenylamine 
• 185827-14-9 1(3-bromo-4-fluorophenyl)3-hydroxypyrrolidin-2-one 
• 1269815-47-5 (3-bromo-4-fluorophenyl)-(tetrahydropyran-4-ylmethyl)carbamic acid tert-butyl ester 
• 1287739-75-6 1-(4-(3-bromo-4-fluorophenylamino)-3-nitrophenyl)-ethanone 
• 1260583-74-1 N-(3-bromo-4-fluorophenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
• 1260584-27-7 N-(3-bromo-4-fluorophenyl)-2-[1-methyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide 
• 1446133-84-1 C₁₉H₁₆BrClFN₃O₂*ClH 
• 1204669-70-4 N-[2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]sulfamide 

Relevant articles and documents

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

Synthesis and structure-activity relationships of new quinolone-type molecules against trypanosoma brucei

Human African trypanosomiasis (HAT) or sleeping sickness is caused by two subspecies of Trypanosoma brucei, Trypanosoma brucei gambiense, and Trypanosoma brucei rhodesiense and is one of Africa's old plagues. It causes a huge number of infections and cases of death per year because, apart from limited access to health services, only inefficient chemotherapy is available. Since it was reported that quinolones such as ciprofloxacin show antitrypanosomal activity, a novel quinolone-type library was synthesized and tested. The biological evaluation illustrated that 4-quinolones with a benzylamide function in position 3 and cyclic or acyclic amines in position 7 exhibit high antitrypanosomal activity. Structure-activity relationships (SAR) are established to identify essential structural elements. This analysis led to lead structure 29, which exhibits promising in vitro activity against T. b. brucei (IC50 = 47 nM) and T. b. rhodesiense (IC50 = 9 nM) combined with low cytotoxicity against macrophages J774.1. Screening for morphological changes of trypanosomes treated with compounds 19 and 29 suggested differences in the morphology of mitochondria of treated cells compared to those of untreated cells. Segregation of the kinetoplast is hampered in trypanosomes treated with these compounds; however, topoisomerase II is probably not the main drug target.

NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.