[(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol

Base Information

Chemical Name:[(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol
CAS No.:158078-04-7
Molecular Formula:C14H16ClN3O4
Molecular Weight:325.752
Hs Code.:
Mol file:158078-04-7.mol

Synonyms:[(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol;4-Chloro-7-(2,3-O-isopropylidene-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Suppliers and Price of [(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
((3AR,4R,6R,6aR)-6-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 97%
250mg
$ 1980.00

Crysdot
((3AR,4R,6R,6aR)-6-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 97%
100mg
$ 990.00

Chemenu
((3AR,4R,6R,6aR)-6-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 97%
100mg
$ 926.00

Total 9 raw suppliers

Chemical Property of [(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol

Chemical Property:

Boiling Point:513.5±50.0 °C(Predicted)
PKA:14.14±0.10(Predicted)
PSA：78.63000
Density:1.68±0.1 g/cm3(Predicted)
LogP:1.49450
Storage Temp.:Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

((3AR,4R,6R,6aR)-6-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol

There total 6 articles about [(3aR,4R,6R,6aR)-6-{4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 16754-80-6
4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 77-76-9
2,2-dimethoxy-propane

: 158078-04-7
[(3aR,4R,6R,6aR)-4-(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 3h;

Reference yield:

: 115479-39-5
4-chloro-7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

: 158078-04-7
[(3aR,4R,6R,6aR)-4-(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 15 ℃;

Reference yield:

: 50-69-1
D-ribose

: 158078-04-7
[(3aR,4R,6R,6aR)-4-(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 3 h / 25 °C

2: 1H-imidazole / dichloromethane / 0.5 h / 0 - 10 °C

3: Hexamethylphosphorous triamide; tetrachloromethane / toluene / 2 h / -30 - 0 °C

4: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / toluene / 20 h / 25 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 °C

With 1H-imidazole; tetrachloromethane; sulfuric acid; Tris(3,6-dioxaheptyl)amine; tetrabutyl ammonium fluoride; potassium hydroxide; Hexamethylphosphorous triamide; In tetrahydrofuran; dichloromethane; toluene;