PSI-7976

Base Information

Chemical Name:PSI-7976
CAS No.:1190308-01-0
Molecular Formula:C22H29FN3O9P
Molecular Weight:529.459
Hs Code.:
Mol file:1190308-01-0.mol

Synonyms:PSI-7976;N-[[P(R),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;Sofosbuvir Impurity 19;Sofosbuvir (R)-Phosphate;(S)-isopropyl 2-((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Suppliers and Price of PSI-7976

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sofosbuvir(R)-Phosphate
2.5mg
$ 340.00

Medical Isotopes, Inc.
Sofosbuvir(R)-Phosphate
2.5 mg
$ 650.00

ChemScene
PSI-7976 98.24%
5mg
$ 4200.00

ChemScene
PSI-7976 98.24%
1mg
$ 1800.00

Total 20 raw suppliers

Chemical Property of PSI-7976

Chemical Property:

PKA:9.39±0.10(Predicted)
PSA：167.99000
Density:1.41±0.1 g/cm3(Predicted)
LogP:2.04740
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), DMSO (Slightly), Ethyl Aceatae (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Sofosbuvir(R)-Phosphate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Technology Process of PSI-7976

There total 28 articles about PSI-7976 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1334513-02-8,1627824-09-2
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

: 1190308-01-0,1496552-16-9
(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester

Guidance literature:: 2'-deoxy-2'-fluoro-2'-methyluridine; With isopropyl magnesium chloride lithium chloride complex; In tetrahydrofuran; at -60 ℃; for 1h;

(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester; In tetrahydrofuran; at -50 ℃; for 1h; Temperature; Reagent/catalyst;

Reference yield: 93.0%

: 1334513-02-8,1627824-09-2
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

: C₁₁H₁₅FN₂O₄

: 1190308-01-0,1496552-16-9
(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester

Guidance literature:: With dmap; N,N-dimethyl-aniline; In tetrahydrofuran; at 5 - 20 ℃; for 5h; Reagent/catalyst; Inert atmosphere; Large scale;

Reference yield: 69.0%

: C₂₁H₃₁N₄O₇P

: C₁₁H₁₅FN₂O₄

: 1190308-01-0,1496552-16-9
(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester

Guidance literature:: C₁₁H₁₅FN₂O₄; With tert-butylmagnesium chloride; In tetrahydrofuran; at -15 - -5 ℃; for 3.5h;

C₂₁H₃₁N₄O₇P; In tetrahydrofuran; at -5 ℃; for 48h;