(S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

Base Information

• Chemical Name: (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
• CAS No.: 1256490-48-8
• Molecular Formula: C₁₈H₂₁N₂O₇P
• Molecular Weight: 408.348
• Mol file: 1256490-48-8.mol

Synonyms:(S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

Chemical Property of (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

There total 10 articles about (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + O-phenyl phosphorodichloridate (770-12-7) + alanine isopropyl ester hydrochloride (39613-92-8,62062-56-0,62062-65-1) → (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester (1256490-48-8)

Guidance literature:

O-phenyl phosphorodichloridate; alanine isopropyl ester hydrochloride; With triethylamine; In dichloromethane; at -10 - -3 ℃; for 0.25h;

4-nitro-phenol; In dichloromethane; for 0.25h;

In dichloromethane;

Reference yield: 75.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + isopropyl (2S)-2-aminopropanoate hydrochloride + O-phenyl phosphorodichloridate (770-12-7) → (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester (1256490-48-8)

Guidance literature:

With triethylamine; In dichloromethane; at -10 - 20 ℃;

Reference yield: 70.0%

→ (S)-2-[(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester (1256490-48-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

upstream raw materials:

1-dichlorophosphoryloxy-4-nitro-benzene

p-nitrophenyl phenyl phosphorochloridate

alanine isopropyl ester hydrochloride

phenol

Downstream raw materials:

sofosbuvir

(S)-2-{(R)-[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid isopropyl ester

(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester