1-BENZYLOXY-5-BROMO-2-METHYLBENZENE

Base Information

• Chemical Name: 1-BENZYLOXY-5-BROMO-2-METHYLBENZENE
• CAS No.: 1114808-93-3
• Molecular Formula: C14H13BrO
• Molecular Weight: 277.161
• Hs Code.: 2909309090
• Mol file: 1114808-93-3.mol

Synonyms:1-BENZYLOXY-5-BROMO-2-METHYLBENZENE;2-Benzyloxy-4-bromo-1-methylbenzene;2-Benzyloxy-4-bromotoluene

Chemical Property of 1-BENZYLOXY-5-BROMO-2-METHYLBENZENE

Chemical Property:

• PSA: 9.23000
• LogP: 4.33650
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyloxy-4-bromotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYLOXY-5-BROMO-2-METHYLBENZENE

There total 1 articles about 1-BENZYLOXY-5-BROMO-2-METHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-bromo-2-methylphenol (36138-76-8) + benzyl bromide (100-39-0) → 2-(benzyloxy)-4-bromo-1-methylbenzene (1114808-93-3)

Guidance literature:

With potassium carbonate; In acetone; for 17h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201402201

Reference yield: 97.0%

2-(benzyloxy)-4-bromo-1-methylbenzene (1114808-93-3) + m-Anisidine (536-90-3,918666-97-4) → 3-benzyloxy-N-(3-methoxyphenyl)-4-methylaniline (1638631-78-3)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In toluene; at 100 ℃; for 18h; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1002/ejoc.201402201

Reference yield: 93.0%

2-(benzyloxy)-4-bromo-1-methylbenzene (1114808-93-3) + (1S,4aS,5S,8aR)-methyl 5-formyl-1,4a,6-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalene-1-carboxylate → (1S,4aS,5S,8aR)-methyl 5-((R)-(3-(benzyloxy)-4-methylphenyl)-(hydroxy)methyl)-1,4a,6-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalene-1-carboxylate

Guidance literature:

2-(benzyloxy)-4-bromo-1-methylbenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

(1S,4aS,5S,8aR)-methyl 5-formyl-1,4a,6-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalene-1-carboxylate; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/acs.joc.7b01551

upstream raw materials:

5-bromo-2-methylphenol

benzyl bromide

Downstream raw materials:

C₁₇H₂₀O₃

C₂₀H₂₇O₅P

C₂₆H₂₉ClO₂

2-hydroxy-3-formyl-7-methoxycarbazole