2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID

Base Information

• Chemical Name: 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID
• CAS No.: 1007875-19-5
• Molecular Formula: C8H8N2O2S
• Molecular Weight: 196.23
• Mol file: 1007875-19-5.mol

Synonyms:2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID;OTAVA-BB 1337727

Chemical Property of 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID

Chemical Property:

• PSA: 82.84000
• LogP: 1.71080

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Dimethylimidazo[2,1-b]thiazole-5-carboxylicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID

There total 4 articles about 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,6-dimethylimidazo<2.1-b>thiazole-5-carboxylate (144836-49-7) → 2,6-dimethylimidazo[2,1-b]thiazole-5-carboxylic acid (1007875-19-5)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 60 ℃; for 7h;

DOI:10.1016/j.bmcl.2016.11.003

Reference yield:

methyl 2,6-dimethylimidazo[2,1-b]thiazole-5-carboxylate → 2,6-dimethylimidazo[2,1-b]thiazole-5-carboxylic acid (1007875-19-5)

Guidance literature:

With lithium hydroxide; In ethanol; for 20h; Reflux;

Reference yield:

5-methyl-2-thiazol-2-amine (7305-71-7) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 2,6-dimethylimidazo[2,1-b]thiazole-5-carboxylic acid (1007875-19-5)

Guidance literature:

5-methyl-2-thiazol-2-amine; ethyl 2-chloro-3-oxo-butyrate; In 1,2-dimethoxyethane; Reflux;

With sodium hydroxide; In water;

upstream raw materials:

5-methyl-2-thiazol-2-amine

ethyl 2-chloro-3-oxo-butyrate

ethyl 2,6-dimethylimidazo<2.1-b>thiazole-5-carboxylate