METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

Base Information

• Chemical Name: METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE
• CAS No.: 866050-80-8
• Molecular Formula: C16H14N2O3
• Molecular Weight: 282.29
• Hs Code.: 2933998090
• Mol file: 866050-80-8.mol

Synonyms:METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE;2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester

Chemical Property of METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

Chemical Property:

• PSA: 52.83000
• LogP: 2.79650

Purity/Quality:

>97% ^*data from raw suppliers

METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

There total 3 articles about METHYL 2-(4-METHOXYPHENYL)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-aminonicotinoate (36052-24-1) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866050-80-8)

Guidance literature:

With sodium carbonate; In ethanol; at 70 ℃;

DOI:10.1016/j.bmc.2020.115574

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866050-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate / 80 °C / Inert atmosphere

2: sodium carbonate / ethanol / 70 °C

With sodium carbonate; copper(ll) bromide; In ethanol; ethyl acetate;

DOI:10.1016/j.bmc.2020.115574

Reference yield:

→ 2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (866050-80-8)

Guidance literature:

upstream raw materials:

methyl 6-aminonicotinoate

2-Bromo-4'-methoxyacetophenone

1-(4-methoxyphenyl)ethanone