D-Proline, 2-methyl-, hydrochloride

Base Information

• Chemical Name: D-Proline, 2-methyl-, hydrochloride
• CAS No.: 123053-48-5
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Hs Code.: 2933990090
• Mol file: 123053-48-5.mol

Synonyms:D-Proline, 2-methyl-, hydrochloride;D-Proline, 2-Methyl-, hydrochloride (9CI);(2R)-2-methylpyrrolidine-2-carboxylic acid hydrochloride;(R)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride

Chemical Property of D-Proline, 2-methyl-, hydrochloride

Chemical Property:

• PSA: 49.33000
• LogP: 1.34390

Purity/Quality:

99%, ^*data from raw suppliers

(2R)-2-Methylpyrrolidine-2-carboxylicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Proline, 2-methyl-, hydrochloride

There total 2 articles about D-Proline, 2-methyl-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (220200-88-4) → (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride (123053-48-5)

Guidance literature:

With hydrogenchloride; In water; toluene; at 75 ℃; for 3h; Temperature;

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride (123053-48-5)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / toluene / 6 h / 57 - 65 °C

2: diisopropylamine; n-butyllithium / tetrahydrofuran / 4 h / -75 - -65 °C

3: hydrogenchloride / toluene; water / 3 h / 75 °C

With hydrogenchloride; n-butyllithium; acetic acid; diisopropylamine; In tetrahydrofuran; water; toluene;

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methyl-D-proline hydrochloride salt (123053-48-5) → (R)-1,2-dimethylpyrrolidine-2-carboxylic acid hydrochloride salt

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃;

upstream raw materials:

L-proline

(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one

Downstream raw materials:

N-benzyloxycarbonyl-glycyl-L-2-methylproline

glycyl-L-2-methylprolyl-L-glutamic acid

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