4-Fluoro-3-hydroxymethyl-benzonitrile

Base Information

• Chemical Name: 4-Fluoro-3-hydroxymethyl-benzonitrile
• CAS No.: 856931-47-0
• Molecular Formula: C8H6FNO
• Molecular Weight: 151.14
• Hs Code.: 2926907090
• Mol file: 856931-47-0.mol

Synonyms:4-Fluoro-3-hydroxymethyl-benzonitrile;BENZONITRILE, 4-FLUORO-3-(HYDROXYMETHYL)-

Chemical Property of 4-Fluoro-3-hydroxymethyl-benzonitrile

Chemical Property:

• PSA: 44.02000
• LogP: 1.18968
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-3-(hydroxymethyl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoro-3-(hydroxymethyl)benzonitrile

Technology Process of 4-Fluoro-3-hydroxymethyl-benzonitrile

There total 2 articles about 4-Fluoro-3-hydroxymethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyano-2-fluorobenzoyl chloride (335256-12-7) → 4-fluoro-3-(hydroxymethyl)benzonitrile (856931-47-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 72h;

Reference yield:

2-fluoro-5-cyanobenzoic acid (146328-87-2) → 4-fluoro-3-(hydroxymethyl)benzonitrile (856931-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / Reflux

2: sodium tetrahydroborate / ethanol; tetrahydrofuran / 72 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; ethanol;

Reference yield: 50.0%

4-fluoro-3-(hydroxymethyl)benzonitrile (856931-47-0) → 3-(bromomethyl)-4-fluorobenzonitrile (856935-35-8)

Guidance literature:

With phosphorus tribromide; In dichloromethane; for 4h;

upstream raw materials:

2-fluoro-5-cyanobenzoic acid

5-cyano-2-fluorobenzoyl chloride

Downstream raw materials:

C₂₄H₁₆FN₃O₂

3-(bromomethyl)-4-fluorobenzonitrile