146328-87-2

Usage

Uses

Used in Pharmaceutical Industry:
5-Cyano-2-fluorobenzoic acid is utilized as an intermediate in the synthesis of various drugs and active pharmaceutical ingredients. Its specific chemical properties make it a valuable component in the development of new medications.
Used in Antimicrobial Applications:
5-CYANO-2-FLUOROBENZOIC ACID has been studied for its potential antimicrobial properties, indicating its use as an antimicrobial agent in various applications where bacterial or fungal control is necessary.
Used in Anticancer Research:
5-Cyano-2-fluorobenzoic acid is also being investigated for its possible anticancer properties, suggesting its use in cancer research and potentially as a therapeutic agent in oncology.
Used in Chemical Synthesis:
Due to its reactivity and the presence of the cyano and fluorine groups, 5-Cyano-2-fluorobenzoic acid is employed in chemical synthesis processes to produce a range of other organic compounds for different industries.

Upstream product

• 337362-21-7 methyl 5-cyano-2-fluorobenzoate 
• 124-38-9 carbon dioxide 
• 79630-23-2 3-bromo-4-fluorobenzonitrile 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 146137-79-3 4-fluoro-3-formylbenzonitrile 
• 7758-19-2 sodium chlorite 
• 10049-21-5 sodium dihydrogenphosphate 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 247568-55-4 5-cyano-2-fluoro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-34-9 2-fluoro-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 335256-12-7 5-cyano-2-fluorobenzoyl chloride 
• 1351565-08-6 2-(5-cyano-2-fluorobenzoyl)hydrazinecarboxylic acid tert-butyl ester 
• 247568-43-0 2-[1-(tert-butoxycarbonyl)-4-piperidinylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-98-9 2-(1-Benzylpiperidin-4-ylamino)-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-97-8 2-[1-(Ethoxycarbonyl)piperidin-4-ylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-41-8 2-[4-(methoxycarbonyl)cyclohexylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247567-04-0 2-[1-(Hydroxymethyl)cyclopentylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 

Relevant academic research and scientific papers

Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides

The use of carbon dioxide as a C1 chemical feedstock remains an active field of research. Here we showcase the use of milled dry ice as a method to promote the availability of CO 2in a reaction solution, permitting practical synthesis of arylcarboxylic acids. Notably, the use of milled dry ice produces marked increases in yields relative to those obtained with gaseous CO 2, as previously reported in the literature.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthr

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

The present application relates to cannabinoid receptor ligands of formula (I) wherein X1, A1, Rx, R2, R3, R4, and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.

Fluorine as an ortho-directing group in aromatic metalation: Generality of the reaction and the high position of fluorine in the Dir-Met potency scale

Many para-substituted fluorobenzenes can be lithiated ortho to fluorine in moderate to good yields, often with one of the dialkylamide bases, lithium diisopropylamide (LDA) or lithium 2,2,6,6-tetramethylpiperidide (LiTMP). Intramolecular competition experiments reveal that fluorine is one of the most potent Dir-Met activating groups under these conditions.