4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Base Information

• Chemical Name: 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
• CAS No.: 1022158-35-5
• Molecular Formula: C12H13BrN2O
• Molecular Weight: 281.152
• Hs Code.: 2934999090
• Mol file: 1022158-35-5.mol

Synonyms:4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;4-bromo-1-(oxan-2-yl)-1H-indazole

Chemical Property of 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Chemical Property:

• PSA: 27.05000
• LogP: 3.49790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

There total 9 articles about 4-BroMo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-(3-(((tert-butyldimethylsilyl)oxy)methyl)-2,4-difluorophenyl)-5-chloropyrimidine-2-carboxylic acid → 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (1022158-35-5)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; at 70 ℃; for 16h;

Reference yield: 96.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-bromoindazole (186407-74-9) → 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (1022158-35-5)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + 4-bromoindazole (186407-74-9) → 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (1022158-35-5) + 4-bromo-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole (1266386-31-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In n-heptane; toluene; at 40 ℃; for 9h; Overall yield = 95 %; Overall yield = 15.2 kg; Inert atmosphere; Large scale;

DOI:10.1021/op3002992

upstream raw materials:

3,4-dihydro-2H-pyran

4-bromoindazole

3-bromo-2-methylaniline

3-fluorobromobenzene

Downstream raw materials:

1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbaldehyde

1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-amine

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