1-(1-phenylpropyl)Piperidine

Base Information

• Chemical Name: 1-(1-phenylpropyl)Piperidine
• CAS No.: 98065-14-6
• Molecular Formula: C₁₄H₂₁N
• Molecular Weight: 0
• Mol file: 98065-14-6.mol

Synonyms:1-(1-phenylpropyl)Piperidine

Chemical Property of 1-(1-phenylpropyl)Piperidine

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(1-phenylpropyl)Piperidine

There total 11 articles about 1-(1-phenylpropyl)Piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-1-piperidin-1-yl-propan-2-one (19134-53-3) → 1-(1-phenyl-propyl)-piperidine (98065-14-6)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; at 120 ℃;

DOI:10.1021/ja01617a036

Reference yield:

piperidine (110-89-4) → 1-(1-phenyl-propyl)-piperidine (98065-14-6)

Guidance literature:

Multi-step reaction with 2 steps

2: hydrazine hydrat, aqueous/water containing/; potassium hydroxide; triethylene glycol / 120 °C

With potassium hydroxide; hydrazine hydrate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol;

DOI:10.1021/ja01617a036

Reference yield:

1-bromo-1-phenyl-2-propanone (23022-83-5) → 1-(1-phenyl-propyl)-piperidine (98065-14-6)

Guidance literature:

Multi-step reaction with 2 steps

2: hydrazine hydrat, aqueous/water containing/; potassium hydroxide; triethylene glycol / 120 °C

With potassium hydroxide; hydrazine hydrate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol;

DOI:10.1021/ja01617a036

upstream raw materials:

N-Formylpiperidine

1-phenyl-propan-1-one

2-phenyl-2-piperidinoacetonitrile

ethylmagnesium bromide

Refernces

• 1、 Jian, Zhongbao,Krupski, Sergei,?koch, Karel,Kehr, Gerald,Daniliuc, Constantin G.,Císa?ová, Ivana,?těpni?ka, Petr,Erker, Gerhard. "Phosphine-Borane Frustrated Lewis Pairs Derived from a 1,1′-Disubstituted Ferrocene Scaffold: Synthesis and Hydrogenation Catalysis". . p. 2940 - 2946. Retrieved 2017/08/21.