MPEG3-NHS

Base Information

• Chemical Name: MPEG3-NHS
• CAS No.: 622405-78-1
• Molecular Formula: C14H23NO8
• Molecular Weight: 333.339
• Mol file: 622405-78-1.mol

Synonyms:MPEG3-NHS;Methyl-PEG4-NHS Ester;1-[(1-Oxo-4,7,10,13-tetraoxatetradec-1-yl)oxy]-2,5-pyrrolidinedione;4,7,10,13-Tetraoxatetradecanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Methyl-PEG4-NHS Ester;m-PEG4-NHS ester;2,5-Dioxopyrrolidin-1-yl 2,5,8,11-tetraoxatetradecan-14-oate

Chemical Property of MPEG3-NHS

Chemical Property:

• Boiling Point: 431.7±55.0 °C(Predicted)
• PSA: 100.60000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: -0.38220
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

97% ^*data from raw suppliers

Methyl-PEG4-NHS Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG4-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of MPEG3-NHS

There total 4 articles about MPEG3-NHS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-propionic acid (125220-94-2,67319-28-2) → triethylene glycol monomethyl ether propionic acid-N-succinimidyl ester (622405-78-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 71.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2,5,8,11-tetraoxatetradecan-14-oyl chloride (848442-01-3) → triethylene glycol monomethyl ether propionic acid-N-succinimidyl ester (622405-78-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → triethylene glycol monomethyl ether propionic acid-N-succinimidyl ester (622405-78-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / 20 °C

2: toluene-4-sulfonic acid; water / 2 h / 80 °C

3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 45 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; water; sodium methylate; toluene-4-sulfonic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

triethylene glucol monomethyl ether

1-hydroxy-pyrrolidine-2,5-dione

2,5,8,11-tetraoxatetradecan-14-oyl chloride

tert-butyl 2,5,8,11-tetraoxatetradecan-14-oate

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