ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate
• CAS No.: 1035262-36-2
• Molecular Formula: C₂₉H₃₉NO₂Si
• Molecular Weight: 461.72
• Mol file: 1035262-36-2.mol

Synonyms:ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate

Chemical Property of ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate

There total 1 articles about ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) + (2-(2-bromo-phenyl)ethynyl)triethylsilane (217469-85-7) → ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate (1035262-36-2)

Guidance literature:

N-benzyl isonipecotic acid ethyl ester; With n-butyllithium; N-cyclohexyl-cyclohexanamine; In toluene; at 20 ℃;

(2-(2-bromo-phenyl)ethynyl)triethylsilane; [PdBrP(t-Bu)3]2; In toluene; at 100 ℃; for 0.333333h;

Reference yield:

ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate (1035262-36-2) → ethyl 1-benzyl-4-(2-ethynylphenyl)piperidine-4-carboxylate (1035262-37-3)

Guidance literature:

With methanol; potassium tert-butylate; at 40 ℃; for 15h;

Reference yield:

ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate (1035262-36-2) → ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate (1035262-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; potassium tert-butylate / 15 h / 40 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

With methanol; n-butyllithium; potassium tert-butylate; diisopropylamine; In tetrahydrofuran;

upstream raw materials:

N-benzyl isonipecotic acid ethyl ester

(2-(2-bromo-phenyl)ethynyl)triethylsilane

Downstream raw materials:

ethyl 1-benzyl-4-(2-ethynylphenyl)piperidine-4-carboxylate

ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate