ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate
• CAS No.: 1035262-38-4
• Molecular Formula: C₂₆H₂₉NO₄
• Molecular Weight: 419.521
• Mol file: 1035262-38-4.mol

Synonyms:ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate

Chemical Property of ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate

There total 4 articles about ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 1-benzyl-4-(2-ethynylphenyl)piperidine-4-carboxylate (1035262-37-3) + chloroformic acid ethyl ester (541-41-3) → ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate (1035262-38-4)

Guidance literature:

ethyl 1-benzyl-4-(2-ethynylphenyl)piperidine-4-carboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.25h;

chloroformic acid ethyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;

Reference yield:

ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate (1035262-36-2) → ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate (1035262-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; potassium tert-butylate / 15 h / 40 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

With methanol; n-butyllithium; potassium tert-butylate; diisopropylamine; In tetrahydrofuran;

Reference yield:

(2-(2-bromo-phenyl)ethynyl)triethylsilane (217469-85-7) → ethyl 1-benzyl-4-(2-(3-ethoxy-3-oxoprop-1-ynyl)phenyl)pipcridine-4-carboxylate (1035262-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / toluene / 20 °C

1.2: [PdBrP(t-Bu)3]2 / 0.33 h / 100 °C

2.1: methanol; potassium tert-butylate / 15 h / 40 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

3.2: 0.5 h / -78 - 20 °C

With methanol; n-butyllithium; potassium tert-butylate; diisopropylamine; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; toluene;

upstream raw materials:

ethyl 1-benzyl-4-(2-ethynylphenyl)piperidine-4-carboxylate

chloroformic acid ethyl ester

ethyl 1-benzyl-4-(2-(2-(triethylsilyl)ethynyl)-phenyl)piperidine-4-carboxylate

N-benzyl isonipecotic acid ethyl ester

Downstream raw materials:

ethyl 4-hydroxy-2-oxo-2',3',5',6'-tetrahydro-N-benzyl-spiro[naphthalene-1,4'-piperidine]-3-carboxylate