Methyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2-carboxylate

Base Information

• Chemical Name: Methyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2-carboxylate
• CAS No.: 1610705-51-5
• Molecular Formula: C12H17BN2O4
• Molecular Weight: 264.089
• Hs Code.: 2933599590
• Mol file: 1610705-51-5.mol

Synonyms:Methyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2-carboxylate;2-(Methoxycarbonyl)pyrimidine-5-boronic Acid Pinacol Ester

Chemical Property of Methyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2-carboxylate

Chemical Property:

• Boiling Point: 396.5±34.0 °C(Predicted)
• PKA: -1?+-.0.22(Predicted)
• Density: 1.16±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(Methoxycarbonyl)pyrimidine-5-boronicacidpinacolester ^*data from reagent suppliers

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Technology Process of Methyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2-carboxylate

There total 1 articles about Methyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-bromopyrimidine-2-carboxylic acid methyl ester (89581-38-4) + bis(pinacol)diborane (73183-34-3) → methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carboxylate (1610705-51-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

Reference yield: 94.0%

methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carboxylate (1610705-51-5) + 5-chloro-3-phenyl-2-((1S)-1-((9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)amino)propyl)quinazolin-4(3H)-one → methyl 5-(4-oxo-3-phenyl-2-((1S)-1-((9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)amino)propyl)-3,4-dihydroquinazolin-5-yl)pyrimidine-2-carboxylate

Guidance literature:

With chloro(crotyl)(2-dicyclohexylphosphino-2’,4’,6’-triisopropybiphenyl)palladium(II); In water; at 100 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-carboxylate (1610705-51-5) + trifluoromethanesulfonic acid 6-[(1S,8R)-5-(2,6-difluoro-phenyl)-11,11-dimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-1-yl]-pyridin-2-yl ester → C28H23F2N5O2

Guidance literature:

With potassium phosphate; [(2-di-tert-butylphosphino-2′,4′,6′-triisopropyl-1, 1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)] palladium(II) methanesulfonate; In 1,4-dioxane; at 20 - 90 ℃; for 20h;

upstream raw materials:

5-bromopyrimidine-2-carboxylic acid methyl ester

bis(pinacol)diborane

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