1,4-dichloro-5-fluorophthalazine

Base Information

• Chemical Name: 1,4-dichloro-5-fluorophthalazine
• CAS No.: 23928-47-4
• Molecular Formula: C₈H₃Cl₂FN₂
• Molecular Weight: 217.03
• Mol file: 23928-47-4.mol

Synonyms:1,4-dichloro-5-fluorophthalazine;PHTHALAZINE, 1,4-DICHLORO-5-FLUORO

Chemical Property of 1,4-dichloro-5-fluorophthalazine

Chemical Property:

• Boiling Point: 400.3±40.0 °C(Predicted)
• PKA: -1.59±0.30(Predicted)
• PSA: 25.78000
• Density: 1.571±0.06 g/cm3(Predicted)
• LogP: 3.07570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

1,4-Dichloro-5-fluorophthalazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-dichloro-5-fluorophthalazine

There total 3 articles about 1,4-dichloro-5-fluorophthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-fluoro-2,3-dihydrophthalazine-1,4-dione (23928-46-3) → 1,4-dichloro-5-fluorophthalazine (23928-47-4)

Guidance literature:

With trichlorophosphate; In neat (no solvent); for 3h; Reflux; Inert atmosphere;

DOI:10.1055/s-0040-1706639

Reference yield: 36.0%

→ 1,4-dichloro-5-fluorophthalazine (23928-47-4)

Guidance literature:

Reference yield:

3-fluorophthalic anhydride (652-39-1) → 1,4-dichloro-5-fluorophthalazine (23928-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / Inert atmosphere

1.2: 24 h / Reflux; Inert atmosphere

2.1: trichlorophosphate / neat (no solvent) / 3 h / Reflux; Inert atmosphere

With hydrazine hydrate; trichlorophosphate; In neat (no solvent);

DOI:10.1055/s-0040-1706639

upstream raw materials:

5-fluoro-2,3-dihydrophthalazine-1,4-dione

3-fluorophthalic anhydride

Refernces

• 1、 Im, Jeong Kyun,Yang, ByeongDo,Jeong, Ilju,Choi, Jun-Ho,Chung, Won-jin. "N-Chlorination-induced, oxidative ring contraction of 1,4-dimethoxyphthalazines". supporting information. . Retrieved 2020/06/03.
• 2、 Cavalleri,Bellasio. "Organic fluoridated organic compounds with potential biologic activity. VI. Synthesis of fluorohydrazinophthalazines". . p. 833 - 846. Retrieved 2007/10/08.