PENTOXIFYLLINE-D6

Base Information

• Chemical Name: PENTOXIFYLLINE-D6
• CAS No.: 1185878-98-1
• Molecular Formula: C₁₃H₁₈N₄O₃
• Molecular Weight: 284.263
• Mol file: 1185878-98-1.mol

Synonyms:PENTOXIFYLLINE-D6;3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione-d6;Trental-d;Vazofirin-d6;1-(5-Oxohexyl)-3,7-dimethylxanthine-d6;1-(5-Oxohexyl)Theobromine-d6;Oxpentifylline-d6;Trental-d6

Chemical Property of PENTOXIFYLLINE-D6

Chemical Property:

• Melting Point: 105°C
• PSA: 78.89000
• LogP: 0.19300
• Storage Temp.: Refrigerator
• Solubility.: Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Pentoxifylline-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled metabolite of Pentifylline. Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Phosphodiesterase inhibitor. Inhibits the synthesis of tumor necrosis factor a (TNF-a). A labelled metabolite of Pentifylline. Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Phosphodiesterase inhibitor. Inhibits the synthesis of tumor necrosis factor α (TNF-α).

Technology Process of PENTOXIFYLLINE-D6

There total 3 articles about PENTOXIFYLLINE-D6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

6-chloro-2-hexanone (10226-30-9) + theobromine-d6 (117490-40-1) → 3,7-di(methyl-d3)-1-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione (1185878-98-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 140 ℃;

Reference yield:

xanthin (69-89-6,6053-41-4) → 3,7-di(methyl-d3)-1-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione (1185878-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 96 h / Reflux

2: toluene / 24 h / 120 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 - 140 °C

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

Reference yield:

tris(trimethylsilyl)xanthine (18641-05-9) → 3,7-di(methyl-d3)-1-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione (1185878-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 24 h / 120 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 - 140 °C

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

6-chloro-2-hexanone

theobromine-d₆

xanthin

tris(trimethylsilyl)xanthine