2-Chloro-9-Methyl-6-Morpholino-9H-purine-8-carboxylic acid

Base Information

• Chemical Name: 2-Chloro-9-Methyl-6-Morpholino-9H-purine-8-carboxylic acid
• CAS No.: 1439824-88-0
• Molecular Formula: C11H12ClN5O3
• Molecular Weight: 297.69768
• Hs Code.: 2934999090
• Mol file: 1439824-88-0.mol

Synonyms:2-chloro-9-methyl-6-morpholin-4-ylpurine-8-carboxylic acid;9H-Purine-8-carboxylic acid, 2-chloro-9-methyl-6-(4-morpholinyl)-

Chemical Property of 2-Chloro-9-Methyl-6-Morpholino-9H-purine-8-carboxylic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-9-methyl-6-morpholino-9H-purine-8-carboxylic acid ^*data from reagent suppliers

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Technology Process of 2-Chloro-9-Methyl-6-Morpholino-9H-purine-8-carboxylic acid

There total 3 articles about 2-Chloro-9-Methyl-6-Morpholino-9H-purine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloro-9-methyl-9H-purin-6-yl)morpholine (1148003-35-3) + chloroformic acid ethyl ester (541-41-3) → 2-chloro-9-methyl-6-morpholino-9H-purine-8-carboxylic acid (1439824-88-0)

Guidance literature:

4-(2-chloro-9-methyl-9H-purin-6-yl)morpholine; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - -40 ℃; for 1.5h; Inert atmosphere;

chloroformic acid ethyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With lithium hydroxide monohydrate; water; In tetrahydrofuran; Reflux;

Reference yield:

4-(2-chloro-9H-purin-6-yl)morpholine (4010-81-5) → 2-chloro-9-methyl-6-morpholino-9H-purine-8-carboxylic acid (1439824-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / acetonitrile / 20 °C

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 1.5 h / -78 - -40 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

2.3: Reflux

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; caesium carbonate; In tetrahydrofuran; hexane; acetonitrile;

Reference yield:

2,6-dichloro-7H-purine (5451-40-1) → 2-chloro-9-methyl-6-morpholino-9H-purine-8-carboxylic acid (1439824-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 2 h / 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 20 °C

3.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 1.5 h / -78 - -40 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

3.3: Reflux

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; caesium carbonate; In tetrahydrofuran; methanol; hexane; acetonitrile;

upstream raw materials:

4-(2-chloro-9H-purin-6-yl)morpholine

4-(2-chloro-9-methyl-9H-purin-6-yl)morpholine

chloroformic acid ethyl ester

2,6-dichloro-7H-purine

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