2-(4-fluorophenyl)-2-methylpropanal

Base Information

• Chemical Name: 2-(4-fluorophenyl)-2-methylpropanal
• CAS No.: 1205638-74-9
• Molecular Formula: C₁₀H₁₁FO
• Molecular Weight: 166.195
• Mol file: 1205638-74-9.mol

Synonyms:2-(4-fluorophenyl)-2-methylpropanal

Chemical Property of 2-(4-fluorophenyl)-2-methylpropanal

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-2-methylpropanal

There total 4 articles about 2-(4-fluorophenyl)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,2-Dimethyl-2-(4-fluorophenyl)ethanol (703-10-6) → 2-(4-fluorophenyl)-2-methylpropanal (1205638-74-9)

Guidance literature:

2,2-Dimethyl-2-(4-fluorophenyl)ethanol; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -60 ℃; for 2h;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at -60 - 20 ℃;

Reference yield: 42.0%

2-(4-fluoro-phenyl)-2-methyl-propionitrile → 2-(4-fluorophenyl)-2-methylpropanal (1205638-74-9)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 - 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201600987

Reference yield:

2-(4-fluorophenyl)-2-methylpropanoic acid (93748-19-7) → 2-(4-fluorophenyl)-2-methylpropanal (1205638-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 20 °C / Inert atmosphere

2: pyridinium chlorochromate; potassium acetate / dichloromethane / 2 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium acetate; pyridinium chlorochromate; In diethyl ether; dichloromethane;

DOI:10.1021/acs.orglett.7b00958

upstream raw materials:

2,2-Dimethyl-2-(4-fluorophenyl)ethanol

2-(4-fluorophenyl)-2-methylpropanoic acid

4-fluorophenylacetonitrile

methyl iodide

Downstream raw materials:

1-fluoro-4-(2-methylbut-3-yn-2-yl)benzene

(E)-4-(4-fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester

Refernces

• 1、 Cai, Xiao,Keshavarz, Amir,Omaque, Justin D.,Stokes, Benjamin J.. "Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes". supporting information. p. 2626 - 2629. Retrieved 2017/05/24.
• 2、 -. "4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES". Page/Page column 35. . Retrieved 2010/03/02.