10-bromobenzo[b]naphtho[1,2-d]furan

Base Information

• Chemical Name: 10-bromobenzo[b]naphtho[1,2-d]furan
• CAS No.: 1256544-20-3
• Molecular Formula: C16H9BrO
• Molecular Weight: 297.151
• Mol file: 1256544-20-3.mol

Synonyms:10-bromobenzo[b]naphtho[1,2-d]furan;Benzo[b]naphtho[1,2-d]furan, 10-bromo-

Chemical Property of 10-bromobenzo[b]naphtho[1,2-d]furan

Chemical Property:

• Boiling Point: 442.9±18.0 °C(Predicted)
• PSA: 13.14000
• Density: 1.557±0.06 g/cm3(Predicted)
• LogP: 5.50170

Purity/Quality:

98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-bromobenzo[b]naphtho[1,2-d]furan

There total 6 articles about 10-bromobenzo[b]naphtho[1,2-d]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-hydroxy-1-(2-fluoro-5-bromophenyl)naphthalene (1256544-19-0) → 10-bromonaphthalene[2,1-b]benzofuran (1256544-20-3)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 2h;

Reference yield:

4-bromo-1-fluoro-2-iodobenzene (116272-41-4) → 10-bromonaphthalene[2,1-b]benzofuran (1256544-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 8 h / Inert atmosphere; Reflux

2.1: boron tribromide / dichloromethane / 24 h / 0 - 20 °C

2.2: -78 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

With boron tribromide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene;

Reference yield:

(2-ethoxynaphthalen-1-yl)boronic acid (148345-64-6) → 10-bromonaphthalene[2,1-b]benzofuran (1256544-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 8 h / Inert atmosphere; Reflux

2.1: boron tribromide / dichloromethane / 24 h / 0 - 20 °C

2.2: -78 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

With boron tribromide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; toluene;

upstream raw materials:

4-bromo-1-fluoro-2-iodobenzene

(2-ethoxynaphthalen-1-yl)boronic acid

2-ethoxy-1-(2-fluoro-5-bromophenyl)naphthalene

2-hydroxy-1-(2-fluoro-5-bromophenyl)naphthalene

Downstream raw materials:

10-(3-bromophenyl)benzo[b]naphtho[1,2-d]furan