1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole

Base Information

Chemical Name:1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole
CAS No.:1396123-91-3
Molecular Formula:C₁₆H₁₈BF₃N₂O₂
Molecular Weight:338.137
Hs Code.:2934999090
Mol file:1396123-91-3.mol

Synonyms:1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole

Suppliers and Price of 1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole

Chemical Property:

PSA：36.28000
LogP:3.19030

Purity/Quality:: ≥99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole

There total 8 articles about 1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13858-07-6
4-iodo-3-phenyl-1,2,3-λ⁵-oxadiazol-3-ium-5-olate

: 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

: 1396123-91-3
1-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

2: 1,2-dichloro-benzene / 72 h / 140 °C / Sealed tube

With copper(l) iodide; In N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1021/ol3021918

Reference yield:

: 3,3,3-trifluoro-2-(phenylamino)propanoic acid

: 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

: 1396123-91-3
1-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic anhydride / dichloromethane / 1 h / 0 - 20 °C

2: 1,2-dichloro-benzene / 72 h / 140 °C / Sealed tube

With trifluoroacetic anhydride; In dichloromethane; 1,2-dichloro-benzene;
DOI:10.1021/ol3021918

Reference yield:

: 622-37-7
Phenyl azide

: 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

: 1396123-91-3
1-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-trifluoromethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 2 h / 20 °C

2: toluene / 2 h / 20 °C

3: lithium iodide / ethyl acetate / 4 h / Reflux

4: isopentyl nitrite / 1,2-dimethoxyethane / 5 h / 20 °C

5: trifluoroacetic anhydride / dichloromethane / 1 h / 0 - 20 °C

6: 1,2-dichloro-benzene / 72 h / 140 °C / Sealed tube

With trifluoroacetic anhydride; lithium iodide; isopentyl nitrite; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-benzene; toluene;
DOI:10.1021/ol3021918