BENZENEETHANIMIDAMIDE, N-HYDROXY-4-(TRIFLUOROMETHYL)-

Base Information

• Chemical Name: BENZENEETHANIMIDAMIDE, N-HYDROXY-4-(TRIFLUOROMETHYL)-
• CAS No.: 176860-56-3
• Molecular Formula: C9H9F3N2O
• Molecular Weight: 218.178
• Mol file: 176860-56-3.mol

Synonyms:BENZENEETHANIMIDAMIDE, N-HYDROXY-4-(TRIFLUOROMETHYL)-

Chemical Property of BENZENEETHANIMIDAMIDE, N-HYDROXY-4-(TRIFLUOROMETHYL)-

Chemical Property:

• Melting Point: 76 - 78 °C (toluene)
• PSA: 58.61000
• LogP: 2.69460

Purity/Quality:

N-HYDROXY-4-(TRIFLUOROMETHYL)BENZENEETHANIMIDAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BENZENEETHANIMIDAMIDE, N-HYDROXY-4-(TRIFLUOROMETHYL)-

There total 2 articles about BENZENEETHANIMIDAMIDE, N-HYDROXY-4-(TRIFLUOROMETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

4-(Trifluoromethyl)phenylacetonitrile (2338-75-2) → (1Z)-N'-hydroxy-2-[4-(trifluoromethyl)phenyl]ethanimidamide (1312766-79-2,176860-56-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In methanol; for 4h; Heating / reflux;

Reference yield:

4-(Trifluoromethyl)phenylacetonitrile (2338-75-2) → N'-hydroxy-2-(4-(trifluoromethyl)phenyl)acetimidamide (176860-56-3)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In ethanol; for 48h; Heating;

DOI:10.1021/jm990229t

Reference yield: 89.0%

(1Z)-N'-hydroxy-2-[4-(trifluoromethyl)phenyl]ethanimidamide (1312766-79-2,176860-56-3) + ethyl chlorocarbonylacetate (36239-09-5) → C14H13F3N2O3 (1028344-71-9)

Guidance literature:

(1Z)-N'-hydroxy-2-[4-(trifluoromethyl)phenyl]ethanimidamide; With sodium hydride; In toluene; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

ethyl chlorocarbonylacetate; In toluene; mineral oil; Inert atmosphere; Reflux;

DOI:10.1021/jm701613h

upstream raw materials:

4-(Trifluoromethyl)phenylacetonitrile

Downstream raw materials:

C-[3-(4-trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-methylamine

(S)-1-[3-(4-Trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-ethylamine

1-methyl-1-[3-(4-trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-ethylamine

2-[3-(4-trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-ethylamine