2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID

Base Information

Chemical Name:2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID
CAS No.:606080-59-5
Molecular Formula:C13H16FNO4
Molecular Weight:269.273
Hs Code.:
Mol file:606080-59-5.mol

Synonyms:2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID;2-((tert-butoxycarbonyl)Methyl)-5-fluorobenzoic acid;2-[[(tert-Butoxycarbonyl)amino]methyl]-5-fluorobenzoic acid

Suppliers and Price of 2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID

Chemical Property:

PSA：75.63000
LogP:2.93950

Purity/Quality:: 97% or 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID

There total 2 articles about 2-(BOC-AMINO)METHYL-5-FLUORO-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 606080-45-9
methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate

: 606080-59-5
2-(((tert-butoxycarbonyl)amino)methyl)-5-fluorobenzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 - 25 ℃; for 24h;
DOI:10.1021/op400228z

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 606080-59-5
2-(((tert-butoxycarbonyl)amino)methyl)-5-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 2 h / 0 - 25 °C

2: sodium hydroxide / tetrahydrofuran / 24 h / 20 - 25 °C

With triethylamine; sodium hydroxide; In tetrahydrofuran;
DOI:10.1021/op400228z

Reference yield: 75.0%

: 1292211-06-3
5-amino-N-methylpentane-1-sulfonamide

: 606080-59-5
2-(((tert-butoxycarbonyl)amino)methyl)-5-fluorobenzoic acid

: 1480815-57-3
tert-butyl 4-fluoro-2-((5-(N-methylsulfamoyl)pentyl)carbamoyl)benzylcarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 10 ℃; for 3h;
DOI:10.1021/op400228z