606080-45-9

Basic information

• Product Name: methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate
• Synonyms: methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate
• CAS NO: 606080-45-9
• Molecular Weight: 283.3
• Mol File: 606080-45-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate(606080-45-9)
• EPA Substance Registry System: methyl 2-((tert-butoxycarbonylamino)methyl)-5-fluorobenzoate(606080-45-9)

Safety Data

• Hazardous Substances Data: 606080-45-9(Hazardous Substances Data)

Upstream product

• 606080-44-8 methyl-2-(aminomethyl)-5-fluorobenzoate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 606080-43-7 methyl 2-cyano-5-fluorobenzoate 

Downstream Products

• 1480815-63-1 5-(5-(2-((aminomethyl)-5-fluorobenzamido)-N-methyl)pentyl)sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxylic acid hydrochloride 
• 1480815-60-8 5-(5-(2-(((tert-butoxycarbonyl)amino)methyl)-5-fluorobenzamido)-N-methylpentylsulfonamido)-8-hydroxy-1,6-naphthyridine-7-carboxylic acid 
• 1480815-58-4 ethyl 5-(5-(2-(((tert-butoxycarbonyl)amino)methyl)-5-fluorobenzamido)-N-methylpentylsulfonamido)-8-hydroxy-1,6-naphthyridine-7-carboxylate 
• 1480815-57-3 tert-butyl 4-fluoro-2-((5-(N-methylsulfamoyl)pentyl)carbamoyl)benzylcarbamate 
• 606080-59-5 2-(((tert-butoxycarbonyl)amino)methyl)-5-fluorobenzoic acid 
• 870562-27-9 methyl 2-(aminomethyl)-5-fluorobenzoate trifluoroacetic acid salt 
• 569354-59-2 N-methyl 2-t-butyloxycarbonylaminomethyl-5-fluorobenzenecarboxamide 

Relevant articles and documents

Copper-catalyzed C-N coupling in the synthesis of integrase inhibitors of immunodeficiency viruses

This contribution describes the total synthesis of a complex macrocyclic integrase inhibitor, a key enzyme involved in the infection process of various immunodeficiency viruses. The key transformation of the synthetic strategy was the selective C-N coupling of a sulfonamide to a heteroaryl bromide in the presence of potentially competing amide and carbamate functionalities. The transformation was accomplished with CuI catalysis using bypiridine as the ligand in the presence of base and enabled a convergent approach to the target molecule.