AKOS BB-8877

Base Information

• Chemical Name: AKOS BB-8877
• CAS No.: 256923-25-8
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.197
• Mol file: 256923-25-8.mol

Synonyms:AKOS BB-8877;4-HYDROXY-7-METHYLQUINOLINE-3-CARBOXYLIC ACID

Chemical Property of AKOS BB-8877

Chemical Property:

• PSA: 70.16000
• LogP: 1.53470

Purity/Quality:

98%min ^*data from raw suppliers

4-hydroxy-7-methylquinoline-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BB-8877

There total 4 articles about AKOS BB-8877 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 4-hydroxy-7-methylquinoline-3-carboxylate (41460-18-8) → 4-hydroxy-7-methylquinoline-3-carboxylic acid (51726-77-3,256923-25-8)

Guidance literature:

With sodium hydroxide; In water; for 0.5h; Reflux;

DOI:10.1016/j.bmc.2013.04.040

Reference yield:

diethyl 2-{[(3-methylphenyl)amino]methylene}propane-1,3-dioate (19056-83-8) → 4-hydroxy-7-methylquinoline-3-carboxylic acid (51726-77-3,256923-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl ether

2: aqueous NaOH

With sodium hydroxide; diphenylether;

Reference yield:

1-amino-3-methylbenzene (108-44-1) → 4-hydroxy-7-methylquinoline-3-carboxylic acid (51726-77-3,256923-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.75 h / 110 °C

2: diphenylether / 0.5 h / Reflux

3: sodium hydroxide / water / 0.5 h / Reflux

With sodium hydroxide; In diphenylether; water;

DOI:10.1016/j.bmc.2013.04.040

upstream raw materials:

ethyl 4-hydroxy-7-methylquinoline-3-carboxylate

diethyl 2-{[(3-methylphenyl)amino]methylene}propane-1,3-dioate

1-amino-3-methylbenzene

Downstream raw materials:

4-chloro-7-methyl-quinoline

4-hydroxy-7-methylquinoline