3-Pyrrolidineacetic acid ethyl ester hydrochloride

Base Information

• Chemical Name: 3-Pyrrolidineacetic acid ethyl ester hydrochloride
• CAS No.: 726139-60-2
• Molecular Formula: C8H16ClNO2
• Molecular Weight: 193.68
• Hs Code.: 2933990090
• Mol file: 726139-60-2.mol

Synonyms:3-Pyrrolidineacetic acid ethyl ester hydrochloride;3-Pyrrolidineacetic acid ethyl ester HCl;Ethyl 2-(pyrrolidin-3-yl)acetate hydrochloride

Chemical Property of 3-Pyrrolidineacetic acid ethyl ester hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.67990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethylpyrrolidine-3-acetatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-(pyrrolidin-3-yl)acetate Hydrochloride is used to prepare GABA uptake inhibitors

Technology Process of 3-Pyrrolidineacetic acid ethyl ester hydrochloride

There total 2 articles about 3-Pyrrolidineacetic acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate (664364-29-8) → 2-pyrrolidin-3-ylacetic acid ethyl ester hydrochloric acid salt (726139-60-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

2-[1-[(tert-butoxy)carbonyl]pyrrolidin-3-yl]acetic acid (175526-97-3) + ethanol (64-17-5) → 2-pyrrolidin-3-ylacetic acid ethyl ester hydrochloric acid salt (726139-60-2)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b01559

Reference yield: 4.0%

2-pyrrolidin-3-ylacetic acid ethyl ester hydrochloric acid salt (726139-60-2) + 1-((4-bromophenoxy)methyl)-2,4-dichlorobenzene → 2-(1-(4-(2,4-dichlorobenzyloxy)phenyl)pyrrolidin-3-yl)acetic acid

Guidance literature:

2-pyrrolidin-3-ylacetic acid ethyl ester hydrochloric acid salt; 1-((4-bromophenoxy)methyl)-2,4-dichlorobenzene; With palladium diacetate; caesium carbonate; johnphos; In 1,4-dioxane; at 120 ℃; for 4h;

With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b01559

upstream raw materials:

2-[1-[(tert-butoxy)carbonyl]pyrrolidin-3-yl]acetic acid

ethanol

tert-butyl 3-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate

Downstream raw materials:

5-bromo-2-[3-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]benzaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 726139-60-2 3-Pyrrolidineacetic acid ethyl ester hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send