(2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE

Base Information

• Chemical Name: (2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE
• CAS No.: 171764-49-1
• Molecular Formula: C₁₄H₁₅F₂N₃O₅S
• Molecular Weight: 375.353
• Mol file: 171764-49-1.mol

Synonyms:(2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE

Chemical Property of (2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE

Chemical Property:

• Vapor Pressure: 7.5E-16mmHg at 25°C
• Boiling Point: 631.4°C at 760 mmHg
• Flash Point: 335.7°C
• PSA: 100.92000
• Density: 1.4g/cm³
• LogP: 3.83380

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

(2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE

There total 4 articles about (2R,4R) CIS-(2,4-DIFLUOROPHENYL)-2-(1,2,4-TRIAZOLE-1-YL-METHYL)-1,3-DIOXOLANE-4YL-METHYL-P-TOLYSULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone (86404-63-9) + (2S)-1,2,3-propanetriol 1-(methylsulfonate) ester → (-)-(2S)-cis-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate ester (171764-50-4,171764-49-1)

Guidance literature:

With methanesulfonic acid; In dichloromethane; for 24h; Heating;

DOI:10.1021/jm0494772

Reference yield:

cis-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol + methanesulfonyl chloride (124-63-0) → (-)-(2S)-cis-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate ester (171764-50-4,171764-49-1)

Guidance literature:

With pyridine; In dichloromethane; chloroform; di-isopropyl ether;

Reference yield:

(2R)-1,2,3-propanetriol 1-(methylsulfonate) ester (53901-53-4) + 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone (86404-63-9) → (+)-(2R)-cis-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate ester (171764-49-1)

Guidance literature:

With methanesulfonic acid; In dichloromethane; for 24h; Heating;

DOI:10.1021/jm0494772

upstream raw materials:

(2R)-1,2,3-propanetriol 1-(methylsulfonate) ester

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

methanesulfonyl chloride

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