3-METHYL-2-AZA-SPIRO[4.4]NONANE

Base Information

• Chemical Name: 3-METHYL-2-AZA-SPIRO[4.4]NONANE
• CAS No.: 883724-28-5
• Molecular Formula: C₉H₁₇N
• Molecular Weight: 139.241
• Mol file: 883724-28-5.mol

Synonyms:3-METHYL-2-AZA-SPIRO[4.4]NONANE

Chemical Property of 3-METHYL-2-AZA-SPIRO[4.4]NONANE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-METHYL-2-AZA-SPIRO[4.4]NONANE

There total 2 articles about 3-METHYL-2-AZA-SPIRO[4.4]NONANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(2-propen-1-yl)cyclopentanemethanamine (883724-27-4) → 3-methyl-2-aza-spiro[4,4]nonane (883724-28-5,914223-79-3)

Guidance literature:

With C₂₅H₃₇BN₄O₂Zr⁽²⁺⁾; In benzene-d6; at 20 ℃; for 11h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja4000189

Reference yield:

1-(2-propen-1-yl)cyclopentanemethanamine (883724-27-4) → 3-methyl-2-aza-spiro[4,4]nonane (883724-28-5,914223-79-3) + C9H15N + C9H19N

Guidance literature:

With C₅₆H₈₆I₂Li₂N₁₂Ta₂; In ⁽²⁾H₈-toluene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.organomet.6b00216

Reference yield:

3-methyl-2-aza-spiro[4,4]nonane (883724-28-5,914223-79-3) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C19H24F3NO2 (1285536-16-4) + C19H24F3NO2 (1285536-15-3)

Guidance literature:

With triethylamine; In benzene; for 1h; Inert atmosphere;

DOI:10.1002/anie.201006163

upstream raw materials:

1-(2-propen-1-yl)cyclopentanemethanamine

Downstream raw materials:

C₁₉H₂₄F₃NO₂

C₁₉H₂₄F₃NO₂

Refernces

• 1、 Helgert, Theodore R.,Zhang, Xiaofei,Box, Hannah K.,Denny, Jason A.,Valle, Henry U.,Oliver, Allen G.,Akurathi, Gopalakrishna,Webster, Charles Edwin,Hollis, T. Keith. "Extreme π-Loading as a Design Element for Accessing Imido Ligand Reactivity. A CCC-NHC Pincer Tantalum Bis(imido) Complex: Synthesis, Characterization, and Catalytic Oxidative Amination of Alkenes". supporting information. p. 3452 - 3460. Retrieved 2016/11/06.
• 2、 Manna, Kuntal,Everett, William C.,Schoendorff, George,Ellern, Arkady,Windus, Theresa L.,Sadow, Aaron D.. "Highly enantioselective zirconium-catalyzed cyclization of aminoalkenes". supporting information. p. 7235 - 7250. Retrieved 2013/06/27.