tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate
• CAS No.: 406212-48-4
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.32
• Mol file: 406212-48-4.mol

Synonyms:tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate

Chemical Property of tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 1.95380

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-(hydroxymethyl)-3-methylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate

There total 7 articles about tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate (888952-55-4) → tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate (406212-48-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.202001123

Reference yield: 77.0%

ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate (278789-43-8) → tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate (406212-48-4)

Guidance literature:

ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate; With lithium triethylborohydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

(3-methylpiperidin-3-yl)methanol (221298-00-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate (406212-48-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

upstream raw materials:

1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate

ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate

(3-methylpiperidin-3-yl)methanol

di-tert-butyl dicarbonate

Downstream raw materials:

7-(3,4-dimethoxyphenyl)-2-((3-(methoxymethyl)-3-methylpiperidin-1-yl)methyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one hydrochloride

(1,3-dimethylpiperidin-3-yl)methanol

C₁₆H₂₃NO₃

C₁₆H₂₃NO₃

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