CHEMBRDG-BB 4016764

Base Information

• Chemical Name: CHEMBRDG-BB 4016764
• CAS No.: 915925-11-0
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• Hs Code.: 2933399090
• Mol file: 915925-11-0.mol

Synonyms:CHEMBRDG-BB 4016764;(1,3-DIMETHYLPIPERIDIN-3-YL)METHANOL;(1,3-dimethylpiperidin-3-yl)methanol(SALTDATA: FREE)

Chemical Property of CHEMBRDG-BB 4016764

Chemical Property:

• Vapor Pressure: 0.333mmHg at 25°C
• Boiling Point: 176.5°C at 760 mmHg
• PKA: 14.93±0.10(Predicted)
• Flash Point: 49.8°C
• PSA: 23.47000
• Density: 0.927g/cm³
• LogP: 0.64850

Purity/Quality:

98% ^*data from raw suppliers

(1,3-Dimethylpiperidin-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 4016764

There total 5 articles about CHEMBRDG-BB 4016764 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate (406212-48-4) → (1,3-dimethylpiperidin-3-yl)methanol (915925-11-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 24.5h; Inert atmosphere; Reflux;

DOI:10.1002/chem.202001123

Reference yield:

1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate (148763-41-1) → (1,3-dimethylpiperidin-3-yl)methanol (915925-11-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 24.5 h / 0 - 20 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium hexamethylsilazane; In tetrahydrofuran; toluene;

DOI:10.1002/chem.202001123

Reference yield:

1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate (888952-55-4) → (1,3-dimethylpiperidin-3-yl)methanol (915925-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 24.5 h / 0 - 20 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/chem.202001123

upstream raw materials:

1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate

1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate

tert-butyl 3-(hydroxymethyl)-3-methylpiperidine-1-carboxylate

nipecotic acid

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