N-Ethyl-2-pyrrolidinecarboxamide hydrochloride

Base Information

• Chemical Name: N-Ethyl-2-pyrrolidinecarboxamide hydrochloride
• CAS No.: 59179-36-1
• Molecular Formula: C₇H₁₄N₂O*ClH
• Molecular Weight: 178.662
• Hs Code.: 2933990090
• Mol file: 59179-36-1.mol

Synonyms:N-Ethyl-2-pyrrolidinecarboxamide hydrochloride

Chemical Property of N-Ethyl-2-pyrrolidinecarboxamide hydrochloride

Chemical Property:

• PSA: 41.13000
• LogP: 1.39620

Purity/Quality:

N-Ethyl-2-pyrrolidinecarboxamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Ethyl-2-pyrrolidinecarboxamide hydrochloride

There total 3 articles about N-Ethyl-2-pyrrolidinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.1%

ethylamine (75-04-7,85404-22-4) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → L-proline ethylamide hydrochloride (58107-62-3,59179-36-1)

Guidance literature:

L-proline; With pyridine; dimethylsilicon dichloride; at 0 ℃; for 2h; Inert atmosphere;

ethylamine; at 0 - 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In water; Temperature;

DOI:10.1007/s10593-014-1474-7

Reference yield:

L-proline + ethylamine (75-04-7,85404-22-4) → L-proline ethylamide hydrochloride (58107-62-3,59179-36-1)

Guidance literature:

L-proline; ethylamine; at 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

DOI:10.1007/s10593-014-1474-7

Reference yield:

dimethylsilicon dichloride (75-78-5,30107-43-8) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → L-proline ethylamide hydrochloride (58107-62-3,59179-36-1)

Guidance literature:

With pyridine; at 0 ℃; for 2h; Temperature; Inert atmosphere;

DOI:10.1007/s10593-014-1474-7

upstream raw materials:

dimethylsilicon dichloride

L-proline

ethylamine

Refernces

• 1、 Balaev,Okmanovich,Osipov,Fedorov. "One-step facile synthesis of l-proline ethylamide hydrochloride". . p. 287 - 289. Retrieved 2015/09/28.