1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt)

Base Information

• Chemical Name: 1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt)
• CAS No.: 200880-42-8
• Molecular Formula: C81H159Na2O16P
• Molecular Weight: 801.071
• Mol file: 200880-42-8.mol

Synonyms:1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt);1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt;L-α-Phosphatidyl-DL-glycerol, distearoyl;Octadecanoic acid (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester monosodium salt;1,2-Distearoyl-sn-glycero-3-PG (sodium salt);18:0 PG

Chemical Property of 1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt)

Chemical Property:

• PSA: 161.46000
• LogP: 11.88940
• Storage Temp.: ?20°C

Purity/Quality:

97% ^*data from raw suppliers

1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: DSPG, also known as 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, is a phospholipid molecule with phosphate polar head connected to two non-polar lipid (stearic acid) by a glycerol molecule. In water, the molecule can orient itself into lipid bilayer and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles.
• Uses: 1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt is used to prepare polyethyleneglycol-modified liposomal doxorubicin for therapies against drug resistant tumors. It is also used in the PEGylated liposomal drug formulation of the anti-cancer agent oxaliplatin.

Technology Process of 1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt)

There total 4 articles about 1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C45H87O10P → C42H82O10P(1-)*Na(1+) (200880-42-8)

Guidance literature:

C₄₅H₈₇O₁₀P; With acetic acid; In methanol; at 25 ℃; for 15h;

With sodium carbonate; In tetrahydrofuran; water; at 25 ℃; for 1h; Solvent;

Reference yield: 88.54%

C49H89O10P → C42H82O10P(1-)*Na(1+) (200880-42-8)

Guidance literature:

C₄₉H₈₉O₁₀P; With trimethylsilyl iodide; In toluene; at -10 - 20 ℃;

With sodium methylate; In methanol; Temperature;

Reference yield:

1,2-distearoyl-sn-glycerol (1429-59-0,10567-21-2) → C42H82O10P(1-)*Na(1+) (200880-42-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; trichlorophosphate / tetrahydrofuran / 3 h / 0 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 40 °C

3.1: acetic acid / methanol / 15 h / 25 °C

3.2: 1 h / 25 °C

With acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol;

upstream raw materials:

1,2-distearoyl-sn-glycerol

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