2-Bromo-5-fluorobenzaldoxime

Base Information

Chemical Name:2-Bromo-5-fluorobenzaldoxime
CAS No.:202865-62-1
Molecular Formula:C₇H₅BrFNO
Molecular Weight:218.025
Hs Code.:2928000090
DSSTox Substance ID:DTXSID60378373
Mol file:202865-62-1.mol

Synonyms:2-Bromo-5-fluorobenzaldoxime;202865-62-1;N-[(2-bromo-5-fluorophenyl)methylidene]hydroxylamine;DTXSID60378373;A814385;N-[(2-bromanyl-5-fluoranyl-phenyl)methylidene]hydroxylamine

Suppliers and Price of 2-Bromo-5-fluorobenzaldoxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-Bromo-5-fluorobenzaldoxime

Chemical Property:

Vapor Pressure:0.00484mmHg at 25°C
Boiling Point:264.6°C at 760 mmHg
Flash Point:113.8°C
PSA：32.59000
Density:1.62g/cm³
LogP:2.39630
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:216.95385
Heavy Atom Count:11
Complexity:153

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)C=NO)Br

Technology Process of 2-Bromo-5-fluorobenzaldoxime

There total 1 articles about 2-Bromo-5-fluorobenzaldoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 202865-62-1
C₇H₅BrFNO

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; water; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b03776

Reference yield:

: 202865-62-1
C₇H₅BrFNO

: 1373820-99-5
7-fluoro-4-phenylisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; hydrogenchloride / ethanol; water / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene; cesium fluoride; tributyltin fluoride / toluene / 2 h / 100 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere; Molecular sieve

With hydrogenchloride; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; tributyltin fluoride; triethylamine; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.orglett.7b03776

Reference yield:

: 202865-62-1
C₇H₅BrFNO

: 7-fluoro-4-(4-fluorophenyl)isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; hydrogenchloride / ethanol; water / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene; cesium fluoride; tributyltin fluoride / toluene / 2 h / 100 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere; Molecular sieve

With hydrogenchloride; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; tributyltin fluoride; triethylamine; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.orglett.7b03776