3-Fluoro-4-isopropoxybenzoic acid

Base Information

• Chemical Name: 3-Fluoro-4-isopropoxybenzoic acid
• CAS No.: 258273-30-2
• Molecular Formula: C10H11FO3
• Molecular Weight: 198.194
• Hs Code.: 2918990090
• Mol file: 258273-30-2.mol

Synonyms:3-Fluoro-4-isopropoxybenzoic acid;3-Fluoro-4-(1-methylethoxy)benzoic acid

Chemical Property of 3-Fluoro-4-isopropoxybenzoic acid

Chemical Property:

• Boiling Point: 304.5±22.0 °C(Predicted)
• PKA: 4.31±0.10(Predicted)
• PSA: 46.53000
• Density: 1.211±0.06 g/cm3(Predicted)
• LogP: 2.31110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-4-isopropoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-4-isopropoxybenzoic acid

There total 4 articles about 3-Fluoro-4-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isopropyl 3-fluoro-4-(1-methylethoxy)benzoate (1198165-93-3) → 3-fluoro-4-isopropoxy-benzoic acid (258273-30-2)

Guidance literature:

isopropyl 3-fluoro-4-(1-methylethoxy)benzoate; With water; sodium hydroxide; In methanol; at 60 ℃; Cooling with ice;

With ammonium chloride; In methanol; water;

Reference yield: 72.0%

methyl 4-(isopropyloxy)-3-fluorobenzoate (1346498-59-6) → 3-fluoro-4-isopropoxy-benzoic acid (258273-30-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 0.333333h;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) → 3-fluoro-4-isopropoxy-benzoic acid (258273-30-2)

Guidance literature:

4-bromo-2-fluoro-1-isopropoxybenzene; With n-butyllithium; In tetrahydrofuran; n-heptane; at -78 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; n-heptane; at 20 ℃;

With hydrogenchloride; sodium hydroxide; water; more than 3 stages;

upstream raw materials:

carbon dioxide

isopropyl 3-fluoro-4-(1-methylethoxy)benzoate

methyl 3-fluoro-4-hydroxybenzoate

methyl 4-(isopropyloxy)-3-fluorobenzoate

Downstream raw materials:

3-fluoro-4-(1-methylethoxy)-N-methoxy-N-methylbenzamide

C₁₀H₁₀ClFO₂