Anlotinib

Base Information

• Chemical Name: Anlotinib
• CAS No.: 1058156-90-3
• Molecular Formula: C23H22FN3O3
• Molecular Weight: 407.44
• Mol file: 1058156-90-3.mol

Synonyms:Anlotinib;1-[[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-quinolinyl]oxy]methyl]cyclopropanamine;Chiglitazar

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Chemical Property of Anlotinib

Chemical Property:

• Boiling Point: 584.4±50.0 °C(Predicted)
• PKA: 16.15±0.30(Predicted)
• PSA: 82.39000
• Density: 1.342±0.06 g/cm3(Predicted)
• LogP: 5.53490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Anlotinib

There total 6 articles about Anlotinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid tert-butyl ester → 1?[[[4?(4?fluoro?2?methyl?1H?indole?5?yl)oxy?6?methoxyquinoline?7?yl]oxy]methyl]cyclopropylamine (1058156-90-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; Cooling with ice;

Reference yield:

1-(((4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropylbenzyl carbamate (1058156-88-9) → 1?[[[4?(4?fluoro?2?methyl?1H?indole?5?yl)oxy?6?methoxyquinoline?7?yl]oxy]methyl]cyclopropylamine (1058156-90-3)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 1h;

Reference yield:

7-(benzyloxy)-4-(2-fluoro-3-((2-methyl-1,3-dioxolan-2-yl)methyl)-4-nitrophenoxy)-6-methoxyquinoline → 1?[[[4?(4?fluoro?2?methyl?1H?indole?5?yl)oxy?6?methoxyquinoline?7?yl]oxy]methyl]cyclopropylamine (1058156-90-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; / 1-methyl-pyrrolidin-2-one / 50 - 55 °C / 750.08 - 1500.15 Torr

2: hydrogenchloride / 1-methyl-pyrrolidin-2-one; water / 50 - 55 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 75 - 85 °C

4: hydrogenchloride / ethanol / 20 °C / Cooling with ice

With hydrogenchloride; hydrogen; potassium carbonate; potassium iodide; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

1-(((4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropylbenzyl carbamate

4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxy-7-hydroxyquinoline

Downstream raw materials:

1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine dihydrochloride