Anlotinib

Base Information

Chemical Name:Anlotinib
CAS No.:1360460-82-7
Molecular Formula:C23H24Cl2FN3O3
Molecular Weight:480.3593632
Hs Code.:
Mol file:1360460-82-7.mol

Synonyms:Anlotinib dihydrochloride;Anlotinib hydrochloride;1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-quinolyl)oxymethyl)cyclopropanamine,dihydrochloride;Cyclopropanamine,1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-quinolinyl)oxy)methyl)-,hydrochloride (1:2);

Suppliers and Price of Anlotinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AnlotinibDihydrochloride
2.5mg
$ 450.00

TRC
AnlotinibDihydrochloride
1mg
$ 225.00

Total 0 raw suppliers

Chemical Property of Anlotinib

Chemical Property:

PSA：82.39000
LogP:7.13890

Purity/Quality:: AnlotinibDihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Anlotinib

There total 13 articles about Anlotinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (1-(((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)cyclopropyl)carbamic acid tert-butyl ester

: 1360460-82-7
1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine dihydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; Isopropyl acetate; at 50 - 55 ℃;

Reference yield: 92.7%

: 1058156-94-7
4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxy-7-(1-acetaminocyclopropan-1-yl)methyloxyquinoline

: 1360460-82-7
1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine dihydrochloride

Guidance literature:: 4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxy-7-(1-acetaminocyclopropan-1-yl)methyloxyquinoline; With sodium hydroxide; In water; isopropyl alcohol; at 60 - 65 ℃; for 4h;

With hydrogenchloride; In water; isopropyl alcohol; at 0 - 5 ℃; for 1h; Solvent; Temperature; Reagent/catalyst;