Cbz-D-Valinol

Base Information

• Chemical Name: Cbz-D-Valinol
• CAS No.: 260978-43-6
• Molecular Formula: C13H19NO3
• Molecular Weight: 237.299
• Mol file: 260978-43-6.mol

Synonyms:Cbz-D-Valinol

Chemical Property of Cbz-D-Valinol

Chemical Property:

• PSA: 58.56000
• LogP: 2.32060

Purity/Quality:

98.5% ^*data from raw suppliers

(R)-Benzyl(1-hydroxy-3-methylbutan-2-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-D-Valinol

There total 8 articles about Cbz-D-Valinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (1R)-1-(hydroxymethyl)-2-methylpropylcarbamate (260978-43-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + (R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) → benzyl (1R)-1-(hydroxymethyl)-2-methylpropylcarbamate (260978-43-6)

Guidance literature:

In 1,4-dioxane; water; at 25 ℃;

DOI:10.1002/chem.200900838

Reference yield:

N-Z-D-valine N-hydroxysuccinimide ester (4467-55-4) → benzyl (1R)-1-(hydroxymethyl)-2-methylpropylcarbamate (260978-43-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;

DOI:10.1002/chem.201302732

upstream raw materials:

N-(Benzyloxycarbonyl)valine methyl ester

(R)-2-amino-3-methylbutanol

benzyl chloroformate

(R)-4-isopropyloxazolidin-2-one

Downstream raw materials:

(R)-3-(benzyloxycarbonyl)-4-isopropyl-[1,2,3]oxathiazolidine 2,2-dioxide

(R)-3-methyl-1-oxobutane-2-benzylcarbamate

tert-butyl(2E,4R)-4-{[(benzyloxy)carbonyl]amino}-5-methyl-2-hexenoate

C₂₁H₃₆NO₆P