Butyric acid 3-fluorophenyl ester

Base Information

• Chemical Name: Butyric acid 3-fluorophenyl ester
• CAS No.: 29052-04-8
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.195
• Mol file: 29052-04-8.mol

Synonyms:Butyric acid 3-fluorophenyl ester

Chemical Property of Butyric acid 3-fluorophenyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.53120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butyric acid 3-fluorophenyl ester

There total 2 articles about Butyric acid 3-fluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

butyric acid (107-92-6) + 4-fluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate → 3-fluorophenyl butyrate (29052-04-8) + n-butyrate de fluoro-4 phenyl (587-89-3) + fluoro-5 hydroxy-2 butyrophenone (575-67-7)

Guidance literature:

butyric acid; 4-fluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate; With sodium hydroxide; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere;

With cesium fluoride; In acetonitrile; at 80 ℃; for 4h; Overall yield = 59 %; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.08.019

Reference yield:

→ 3-fluorophenyl butyrate (29052-04-8)

Guidance literature:

Reference yield:

3-fluorophenyl butyrate (29052-04-8) + N-tert-butoxycarbonyl-3-piperidinol (85275-45-2) → tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate (143900-43-0) + tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate (143900-44-1) + 3-(S)-butyroxy-N-Boc-piperidine

Guidance literature:

With savinase enzyme; sodium carbonate; In toluene; at 40 ℃; for 40h; Resolution of racemate; Sealed tube; Enzymatic reaction;

upstream raw materials:

butyric acid

Downstream raw materials:

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Refernces

• 1、 -. "Method of treating depression using azabicyclohexanes". . . Retrieved 2008/06/13.