DepropylaMino Hydroxy Propafenone

Base Information

• Chemical Name: DepropylaMino Hydroxy Propafenone
• CAS No.: 91401-73-9
• Molecular Formula: C₁₈H₂₀O₄
• Molecular Weight: 300.354
• Mol file: 91401-73-9.mol

Synonyms:DepropylaMino Hydroxy Propafenone;1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyl-1-propanone;Despropylamino Hydroxy Propafenone

Chemical Property of DepropylaMino Hydroxy Propafenone

Chemical Property:

• PSA: 66.76000
• LogP: 2.23410
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

Depropylamino Hydroxy Propafenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Depropylamino Hydroxy Propafenone (Propafenone EP Impurity D) is a metabolite of the sodium channel blocker Propafenone (P757500). A metabolite of the sodium channel blocker Propafenone (P757500).

Technology Process of DepropylaMino Hydroxy Propafenone

There total 7 articles about DepropylaMino Hydroxy Propafenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-2,2-dimethyl-4-{2-[2-(2-phenylethyl)-1,3-dioxolan-2-yl]phenoxymethyl}-1,3-dioxolane (189766-46-9) → 1-[2-((R)-2,3-Dihydroxy-propoxy)-phenyl]-3-phenyl-propan-1-one (189766-47-0,91401-73-9)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 50 ℃; for 1h;

DOI:10.1007/BF00807638

Reference yield: 10.0%

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one (22525-95-7) → 2-(2',3'-dihydroxy-propoxy)-ω-phenyl-propiophenone (91401-73-9)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; at 70 ℃; for 14h;

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-(2',3'-dihydroxy-propoxy)-ω-phenyl-propiophenone (91401-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 50percent NaOH, 2.) H₂ / 2.) Pd-charcoal / 1.) methanol, r.t., 60 h, 2.) methanol, normal pressure

3: 10 percent / 1N H₂SO₄ / tetrahydrofuran / 14 h / 70 °C

With sodium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

upstream raw materials:

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

2'-hydroxy-3-phenylpropiophenone

o-hydroxyacetophenone

benzaldehyde