7-fluoro-2-oxo-1,5-Naphthyridine-1(2H)-acetaldehyde

Base Information

Chemical Name:7-fluoro-2-oxo-1,5-Naphthyridine-1(2H)-acetaldehyde
CAS No.:959615-66-8
Molecular Formula:C10H7FN2O2
Molecular Weight:206.176
Hs Code.:
Mol file:959615-66-8.mol

Synonyms:7-fluoro-2-oxo-1,5-Naphthyridine-1(2H)-acetaldehyde;2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-fluoro-2-oxo-1,5-Naphthyridine-1(2H)-acetaldehyde

Chemical Property:

PSA：51.96000
LogP:0.73450

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 7-fluoro-2-oxo-1,5-Naphthyridine-1(2H)-acetaldehyde

There total 1 articles about 7-fluoro-2-oxo-1,5-Naphthyridine-1(2H)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884495-03-8
3-amino-2-bromo-5-fluoropyridine

: 959615-66-8
2-(7-fluoro-2-oxo-1,2-dihydro-1,5-naphthyridin-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 5 h / 145 - 150 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 - 60 °C

2.2: 4 h / 85 - 95 °C

3.1: water; trifluoroacetic acid / 4.08 h / 20 - 90 °C

3.2: pH 7.4

With water; sodium hydride; triethylamine; trifluoroacetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 959615-66-8
2-(7-fluoro-2-oxo-1,2-dihydro-1,5-naphthyridin-1-yl)acetaldehyde

: (3aS,6S,7aR)-6-amino-3-{4-[(4-methoxyphenyl)methyl]-3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-6-yl}octahydro-1,3-benzoxazol-2-one

: 1-(2-{[(3aS,6S,7aR)-3-{4-[(4-methoxyphenyl)methyl]-3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-6-yl}-2-oxooctahydro-1,3-benzoxazol-6-yl]amino}ethyl)-7-fluoro-1,2-dihydro-1,5-naphthyridin-2-one

Guidance literature:: 2-(7-fluoro-2-oxo-1,2-dihydro-1,5-naphthyridin-1-yl)acetaldehyde; (3aS,6S,7aR)-6-amino-3-{4-[(4-methoxyphenyl)methyl]-3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-6-yl}octahydro-1,3-benzoxazol-2-one; In dichloromethane; at 20 ℃; for 2h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 2h; Molecular sieve;