884495-03-8

Basic information

• Product Name: 3-Amino-2-bromo-5-fluoropyridine
• Synonyms: 3-AMINO-2-BROMO-5-FLUOROPYRIDINE;2-bromo-5-fluoropyridin-3-amine;2-Bromo-5-fluoro-3-pyridinamine;2-broMo-5-fluoro-3-aMinopyridine
• CAS NO: 884495-03-8
• Molecular Formula: C₅H₄BrFN₂
• Molecular Weight: 191
• Product Categories: Pyridine;Fluorine series
• Mol File: 884495-03-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 114-116 °C
• Boiling Point: 273.6 °C at 760 mmHg
• Flash Point: 119.3 °C
• Appearance: /
• Density: 1.813 g/cm³
• Vapor Pressure: 0.00566mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.50±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-2-bromo-5-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-bromo-5-fluoropyridine(884495-03-8)
• EPA Substance Registry System: 3-Amino-2-bromo-5-fluoropyridine(884495-03-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 884495-03-8(Hazardous Substances Data)

Usage

General Description

3-Amino-2-bromo-5-fluoropyridine is a chemical compound with the molecular formula C5H4BrFN2. It is a pyridine derivative with a bromine and fluorine substituent at the 2 and 5 positions, respectively, and an amino group at the 3 position. 3-Amino-2-bromo-5-fluoropyridine is used as a building block in the synthesis of pharmaceuticals and agricultural chemicals. It is also utilized as a reagent in organic synthesis for the creation of various pyridine derivatives. 3-Amino-2-bromo-5-fluoropyridine has potential applications in the field of medicinal chemistry and drug discovery due to its unique structural features. However, it is important to handle this chemical with caution as it may pose hazards to health and the environment if not properly managed.

InChI:InChI=1/C5H4BrFN2/c6-5-4(8)1-3(7)2-9-5/h1-2H,8H2

Upstream product

• 652160-72-0 2-bromo-5-fluoro-3-nitropyridine 

Downstream Products

• 1190320-33-2 6-fluoro-1H-pyrrolo[3,2-b]pyridine 
• 1445856-42-7 6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridine 
• 1445856-43-8 6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridine 4-oxide 
• 1445856-44-9 6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile 
• 1445856-45-0 1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone 
• 1445856-46-1 1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone oxime 
• 1445856-40-5 1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanamine 
• 1445856-48-3 6-fluoro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile 
• 1445856-49-4 6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile 
• 1445856-50-7 (6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)methanamine 
• 1445856-51-8 tert-butyl (6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)methylcarbamate 
• 1445856-52-9 tert-butyl (6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)methyl(methyl)carbamate 
• 1445856-47-2 (6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N-methylmethanamine 
• 1445856-75-6 N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)pyrimidine-2,4-diamine 

Relevant articles and documents

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.