(S)-1-Methoxymethyl-2-methyl-propylamine

Base Information

• Chemical Name: (S)-1-Methoxymethyl-2-methyl-propylamine
• CAS No.: 64715-88-4
• Molecular Formula: C6H15NO
• Molecular Weight: 117.19
• Mol file: 64715-88-4.mol

Synonyms:(S)-1-Methoxymethyl-2-methyl-propylamine;(S)-1-Methoxy-3-methylbutan-2-amine

Chemical Property of (S)-1-Methoxymethyl-2-methyl-propylamine

Chemical Property:

• PSA: 35.25000
• LogP: 1.31640

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-Methoxymethyl-2-methyl-propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-Methoxymethyl-2-methyl-propylamine

There total 8 articles about (S)-1-Methoxymethyl-2-methyl-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-valinol (2026-48-4,473-75-6) + methyl iodide (74-88-4) → (S)-2-amino-1-methoxy-3-methylbutane (64715-88-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1021/jo00399a021

Reference yield:

(S)-N-(1-(1-methylethyl)-2-methoxyethyl)-2,4-dinitrophenylsulfonamide (1313186-67-2) → (S)-2-amino-1-methoxy-3-methylbutane (64715-88-4)

Guidance literature:

With thiophenol; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

DOI:10.1002/ejoc.201100358

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (S)-2-amino-1-methoxy-3-methylbutane (64715-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / NaBH₄*BF₃

2: NaH

With sodium tetrahydroborate; boron trifluoride; sodium hydride;

DOI:10.1016/S0040-4020(01)88523-9

upstream raw materials:

(S)-valinol

methyl iodide

N-benzylidene-O-methyl-L-valinol

L-valine ethyl ester

Downstream raw materials:

N-(1-methoxymethyl-2-methylpropyl)benzoylformamide

N-((S)-1-methoxy-3-methyl-2-butyl)-2-phenylbutyramide

(S)-N-<(S)-1-methoxymethyl-2-methylpropyl>mandelamide

(R)-N-<(S)-1-methoxymethyl-2-methylpropyl>mandelamide